复方丹参注射液预防硝酸甘油控制性降压致动脉血氧分压下降的临床研究

作者	单位
郑利民	湖北医科大学附属第一医院麻醉学教研室!武汉430060
胡岚	湖北医科大学附属第一医院麻醉学教研室!武汉430060
陈雪君	湖北医科大学附属第一医院麻醉学教研室!武汉430060

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中文摘要:

目的 :观察复方丹参注射液对硝酸甘油 (NTG)控制性降压时动脉血气改变的影响。方法 :1 6例在全身麻醉、控制性降压下择期手术的成人患者 ,随机分成对照组与丹参组(各 8例 )。两组均用NTG控制性降压 ,血压下降幅度约为对照值的 3 0 % ,丹参组在降压前静脉注射复方丹参注射液 1 6ml。结果 :对照组在降压期间动脉血氧分压 (PaO2 )显著下降 ,动脉血于呼气末二氧化碳分压差 (Pa etCO2 )显著升高 ,而丹参组血气无显著性改变。结论 :复方丹参注射液可预防NTG对血气的不良影响。

英文摘要:

Objective: To observe the effects of Salvia Miltiorrhizae Composita (SMC) on blood gas variations of nitroglycerin (NTG) controlled hypotension. Methods: Sixteen patients who were arranged to undergo operation under general anesthesia in controlled hypotension condition were divided randomly into control group (n=8) and SMC group (treated group, n=8), NTG were used to create controlled hypotension in both groups and blood pressure decrease about 30% comparing with the control values. Patients in the treated group were administered intravenously with SMC (16 ml) before the utilization of NTG. Results: Significant PaO 2 decrease and Pa etCO 2 increase were observed in the control group during the controlled hypotension period. However, blood gas values in the treated group did not evidently change.Conclusion: It suggested that SMC can prevent the side effects of NTG on blood gas.

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