注射用双黄连治疗小儿病毒性心肌炎疗效观察

作者	单位
林国珍	上海第二医科大学附属瑞金医院儿内科!上海200025
刘冬梅	上海第二医科大学附属瑞金医院儿内科!上海200025
朱霖	上海第二医科大学附属瑞金医院儿内科!上海200025
邱定众	上海第二医科大学附属瑞金医院儿内科!上海200025

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中文摘要:

目的 :探讨病毒性心肌炎患儿免疫功能状态及双黄连的干预作用。方法 :用ELISA及间接免疫荧光法测定了 62例心肌炎患儿血清中柯萨奇B组病毒抗体 (COXB IgM)及T细胞亚群CD+3 、CD+4、CD+8、CD+4/CD+8,并将其随机分成两组 :双黄连组 (3 2例 ,在常规西药基础上加用双黄连 )及常规组 (3 0例 ,除不用双黄连外 ,其余相同 )。结果 :62例心肌炎患儿中 ,3 9例COXB IgM阳性和正常对照有显著性差异 (P <0 0 0 1 ) ;患儿CD+4下降 ,CD+8上升 ,CD+4/CD+8下降 ,用双黄连治疗后 ,患儿临床症状、体征及免疫功能的恢复均优于常规组 (P <0 0 1 )。结论 :病毒性心肌炎患儿存在免疫功能异常及免疫调节功能紊乱 ,注射用双黄连粉剂为治疗小儿病毒性心肌炎的有效药物。

英文摘要:

Objective: To study immune function of children viral myocarditis and to evaluate the clinical effect of Shuanghuanglian Powder (SHLP). Methods: The authors determined serum COXB IgM and the numbers of lymphocyte subsets CD + 3, CD + 4, CD + 8, CD + 4/CD + 8 with viral myocarditis patients by ELISA and indirect immunofluorescent assay. Sixty two cases were divided randomly into two groups. Thirty two cases treated by conventional therapy with SHLP and the other 30 cases treated with conventional therapy alone were taken as control group. Results: COXB IgM was positive in 39 of 62 patients, which were significantly different with those of normal controls (P<0 001). In addition, the level of CD + 4 cells and the ratio of CD + 4/CD + 8 were decreased while CD + 8 increased. After treatment with SHLP, the recovery of symptoms, signs and immune function in patients were better than that of controls. These changes were significantly different (P<0 01). Conclusions: There were disturbance of immune regulatory function with children viral myocarditis patients and SHLP is an effective drug in treating children viral myocarditis.

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