醒脑静治疗急性酒精中毒的临床和实验研究

作者	单位
白静贞	Bai Jingzhen, Zeng Qing, Chai Zhinan, et al Department of Emergency Medicine, China Japan Friendship Hospital, Beijing (100029
曾庆	Bai Jingzhen, Zeng Qing, Chai Zhinan, et al Department of Emergency Medicine, China Japan Friendship Hospital, Beijing (100029
柴枝楠	Bai Jingzhen, Zeng Qing, Chai Zhinan, et al Department of Emergency Medicine, China Japan Friendship Hospital, Beijing (100029
贾寒冬	Bai Jingzhen, Zeng Qing, Chai Zhinan, et al Department of Emergency Medicine, China Japan Friendship Hospital, Beijing (100029
郝阿娟	Bai Jingzhen, Zeng Qing, Chai Zhinan, et al Department of Emergency Medicine, China Japan Friendship Hospital, Beijing (100029
李爱科	Bai Jingzhen, Zeng Qing, Chai Zhinan, et al Department of Emergency Medicine, China Japan Friendship Hospital, Beijing (100029

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中文摘要:

目的 :探讨中药醒脑静注射液治疗急性酒精中毒 (酒厥 )的机理。方法 :选择单纯酒厥急诊患者 (8例 )及实验家兔模型 (2 6只 ) ,静脉用醒脑静注射液治疗 ,用药前及清醒后分别测定血浆β-内啡肽、氧自由基、超氧化物歧化酶 (SOD)。结果 :醒脑静在促醒酒厥家兔模型及患者的同时 ,β -内啡肽从酒厥时明显高于健康人 ,降低至接近正常水平 (家兔酒厥时 1 2 7 0 9±1 3 67ng/L、清醒时 41 48± 7 46ng/L ,P <0 0 1 ;患者酒厥时 2 92 97± 1 4 85ng/L ,清醒时2 2 1 60± 1 5 95ng/L ,P <0 0 1 )。家兔模型及患者的血浆氧自由基与 β -内啡肽有同步变化(家兔酒厥时 3 1 3 3 9± 1 5 64u/L、清醒时 2 5 4 2 7± 2 1 71u/L ,P <0 0 1 ;患者酒厥时 2 78 47±1 1 1 8u/L、清醒时 1 5 9 92± 1 1 5 1u/L ,P <0 0 1 ) ,SOD呈反向改变 (家兔酒厥时 5 3 5 7±6 48%、清醒时 77 1 8± 7 89% ,P <0 0 1 ;患者酒厥时 43 76± 7 84% ,清醒时 82 5 3± 4 3 3 % ,P <0 0 1 )。结论 :醒脑静注射液具有与纯阿片受体拮抗剂纳络酮相同的药理作用 ,且是一种有效的抗氧化剂 ,临床可用于治疗酒厥。

英文摘要:

Objective: To study the therapeutical mechanism of traditional Chinese medicine Xingnaojing injection (XNJI) for acute alcohol intoxication. Methods: XNJI was used in treating the experimental model rabbits (n=26) and the patients (n=8) admitted to the emergency department with acute alcoholism. Before and after the treatment, β-EP, superoxide anion (free radicals) and SOD were measured. Results: XNJI could enhance the regaining consciousness of rabbits and patients, simultaneously reduce the concentration of β EP in plasma to the normal level (drunk rabbits 127.09±13.67 ng/L, normal rabbits 41.48±7.46 ng/L. P<0 01, drunk patients 292.97±14.85 ng/L, normal people 221.60±15.95 ng/L,P<0 01). The concentration change of superoxide anion (free radicals) in plasma of rabbits and patients was similar to β EP (drunk rabbits 313.39±15.64 u/L, normal rabbits 254.27±21.71 u/L, P<0 01; drunk patients 278.47±11.48 u/L, normal people 159.92±11.51 u/L,P<0 01), and SOD was inversely changed (drunk rabbits 53.57±6.48%, normal rabbits 77.18±7.89%,P<0 01; drunk patients 43.76±7.84%, normal people 82.53±4.33%,P<0 01). Conclusions: XNJI is similar to Naloxone in pharmacologic action. And it is an effective antioxidant. It can be used for treating alcoholism.

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