益寿调脂片抗高脂血症及动脉粥样硬化的实验研究

目的 :观察益寿调脂片对兔高脂血症、动脉粥样硬化模型中脂质代谢和主动脉内膜斑块形成的影响。方法 :将 3 2只家兔随机分为 4组 (每组 8只 ) :益寿调脂片组喂高脂饲料加益寿调脂片 1 5 9g·kg- 1 ·d- 1 ,绞股蓝总甙片组喂高脂饲料加绞股蓝总甙片 2 2 5 4mg·kg- 1 ·d- 1 ,高脂组喂高脂饲料 ,正常组喂普通饲料 ,6周后测定有关生化指标并进行病理形态学检查。结果 :(1 )益寿调脂片组血清总胆固醇 (TC)、甘油三酯 (TG)、动脉粥样硬化指数 (AI)、载脂蛋白B(ApoB)、脂蛋白 (a)〔Lp(a)〕、氧化型低密度脂蛋白 (ox LDL)、羟脯氨酸 (HYP)、钙离子浓度(Ca2 +)、血栓素B2 (TXB2 )均较绞股蓝总甙片组和高脂组明显降低 (P <0 0 0 1 ) ,而血清高密度脂蛋白胆固醇 (HDL C)、载脂蛋白A1 (ApoA1 )、6 酮前列腺素F1α(6 keto PGF1α)及ApoA1 /ApoB比值明显升高 (P <0 0 0 1 )。 (2 )病理形态学检查显示益寿调脂片组兔主动脉斑块面积明显减少 ,动脉内膜增厚不明显 ,未见显著的平滑肌细胞增生及弹力纤维形成。结论 :益寿调脂片能对抗实验性高脂血症及动脉粥样硬化的形成 ,是防治高脂血症、动脉粥样硬化理想而有效的药物。

英文摘要:

Objective: To observe the effect of Yishou Tiaozhi tablet on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit’s model of experimental hyperlipemia and atherosclerosis. Methods: Thirty two rabbits were divided randomly into four groups, group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of Yishou Tiaozhi tablet was fed to the group A every day; to the group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; to the group C, forage with cholesterol and lipid was fed; and to the group D, ordinary forage only. Biochemical parameters were measured and pathomorphological examination were carried out 6 weeks later. Results: (1) Yishou Tiaozhi tablet obviously lowered the levels of serum TC, TG, AI, ApoB, LP (a), ox LDL, HYP, plasma Ca 2+ , TXB 2 and increased the levels of serum HDL ch, ApoA 1, ApoA 1/APoB, plasma 6 keto PGF 1α (P<0 01).(2)Pathomorphological examination showed that in the group A aortic intimal atherosclerotic plaque area and arterial intima thickness obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not seen. Conclusion: Yishou Tiaozhi tablet can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.

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