含川芎嗪腹透液对腹膜透析效能的影响

作者	单位
陆才生	Lu Caisheng, Ye Rengao, Sun Lin, et al Institute of Kidney, First Affiliated Hospital of Sun Yat sen University of Medical Sciences, Guangzhou (510080)
叶任高	Lu Caisheng, Ye Rengao, Sun Lin, et al Institute of Kidney, First Affiliated Hospital of Sun Yat sen University of Medical Sciences, Guangzhou (510080)
孙林	Lu Caisheng, Ye Rengao, Sun Lin, et al Institute of Kidney, First Affiliated Hospital of Sun Yat sen University of Medical Sciences, Guangzhou (510080)
李惠群	Lu Caisheng, Ye Rengao, Sun Lin, et al Institute of Kidney, First Affiliated Hospital of Sun Yat sen University of Medical Sciences, Guangzhou (510080)
郑智华	Lu Caisheng, Ye Rengao, Sun Lin, et al Institute of Kidney, First Affiliated Hospital of Sun Yat sen University of Medical Sciences, Guangzhou (510080)
戴健霞	Lu Caisheng, Ye Rengao, Sun Lin, et al Institute of Kidney, First Affiliated Hospital of Sun Yat sen University of Medical Sciences, Guangzhou (510080)

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中文摘要:

目的 :观察川芎嗪对腹膜透析效能的影响。方法 :采用自身前后对照设计 ,按腹膜平衡试验 (PET)结果将 2 4例稳定的持续非卧床腹膜透析 (CAPD)患者分为腹膜高转运 (4例 )、高于平均转运 (1 1例 )、低于平均转运 (8例 )、低转运 (1例 ) 4组 ,观察各组在腹透液中加入川芎嗪 (2 40mg/d)前后每透析周期平均净出超量 (UF)及每周尿素氮清除指数 (KT/V)的变化。结果 :加入川芎嗪后 2 4例患者的UF及每周KT/V值均有显著提高 (P <0 0 1 ) ,在不同腹膜转运的各组内 ,除高转运组 4例患者每周KT/V值升高未达到有显著统计学意义以外 ,每组的UF及其余组的每周KT/V值均有明显提高 (P <0 0 5 ,P <0 0 1 )。结论 :腹透液中加入川芎嗪能提高腹膜透析效能 ,增加出超量 ,值得进一步研究。

英文摘要:

Objective: To observe the influence of ligustrazine on efficiency of peritoneal dialysis. Methods: A prospective, self controlled study was adopted, 24 stable continuous ambulatory peritoneal dialysis (CAPD) patients were divided into 4 groups according to their peritoneal membrane solute transport types identified by peritoneal equilibration test (PET), the high transport group (H group, 4 cases), the high average transport group (Ha group, 11 cases), the low average transport group (La group, 8 cases) and the low transport group (L group, 1 case). After treated with standard dialysis for 2 weeks, patients were treated by peritoneal dialysis with ligustrazine (240 mg/d) contained dialysate for another 2 weeks, and changes on mean net ultrafiltration volume (UF) per exchange, and urea kinetics (KT/V) per week of patients were observed. Results: After ligustrazine treatment, the UF and KT/V raised significantly, P<0 01. In comparison of groups with different transportation, except change on UF of the H group was insignificant, increment of both parameters before and after treatment were significant (P<0 01 or 0.05). Conclusion: By adding ligustrazine in standard dialysate can enhance the efficiency of peritoneal dialysis, raise the UF, so is worth further study.

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