胃舒胶囊治疗萎缩性胃炎癌前病变的临床研究

作者	单位
陆为民	Lu Weimin, Shan Zhaowei, Shen Hong, et al Institute of Digestive Diseases, Jiangsu Provincial Hospital of TCM, Nanjing (210029
单兆伟	Lu Weimin, Shan Zhaowei, Shen Hong, et al Institute of Digestive Diseases, Jiangsu Provincial Hospital of TCM, Nanjing (210029
沈洪	Lu Weimin, Shan Zhaowei, Shen Hong, et al Institute of Digestive Diseases, Jiangsu Provincial Hospital of TCM, Nanjing (210029
吴静	Lu Weimin, Shan Zhaowei, Shen Hong, et al Institute of Digestive Diseases, Jiangsu Provincial Hospital of TCM, Nanjing (210029
朱云华	Lu Weimin, Shan Zhaowei, Shen Hong, et al Institute of Digestive Diseases, Jiangsu Provincial Hospital of TCM, Nanjing (210029
朱长乐	Lu Weimin, Shan Zhaowei, Shen Hong, et al Institute of Digestive Diseases, Jiangsu Provincial Hospital of TCM, Nanjing (210029

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中文摘要:

目的 :探讨胃舒胶囊对萎缩性胃炎癌前病变的治疗作用及机理。方法 :75例萎缩性胃炎癌前病变患者随机分为两组 ,治疗组 (45例 )给予胃舒胶囊口服 ,对照组 (3 0例 )给予胃宁冲剂冲服 ,疗程均为 6个月。观察两组患者临床、病理疗效 ,治疗前后萎缩、肠化、异型增生、肠化亚型和癌胚抗原 (CEA)、增殖细胞核抗原 (PCNA)表达积分值的变化。结果 :治疗组临床总有效率为 91 % ,对萎缩、肠化、异型增生的有效率分别为 64 %、67%、65 % ,并能降低其积分值 ,与对照组比较有显著性差异 (P <0 0 1 ,P <0 0 5 ) ;治疗前后免疫组化结果显示胃舒胶囊对肠化亚型和CEA、PCNA的表达也有明显的改善和阻抑作用 (P <0 0 1 )。结论 :胃舒胶囊对萎缩性胃炎癌前病变的临床症状及病理变化有显著改善作用 ,其机理可能与其诱导和促进肠化细胞、异型增生细胞的分化成熟 ,抑制和纠正细胞的异常增殖有关。

英文摘要:

Objective: To explore the therapeutic effect and mechanism of Weishu capsule (WSC) in treating precancerous lesions of chronic atrophic gastritis (CAG). Methods: Seventy five cases of precancerous lesions of CAG were distributed to two groups randomly, the treated group (45 patients) treated with WSC by taken orally and the control group (30 patients) treated with Weining granule (WNG) orally. The treatment course of both groups were 6 months. The clinical and pathological effects and the changes in scores of atrophy, intestinal metaplasia and its subgroups, dysplasia, carcinoembryonic antigen (CEA) and proliferating cell nuclear antigen (PCNA) expression were observed before and after treatment. Results: The total effective rate was 91% and the effective rate of atrophy, intestinal metaplasia, dysplasia in the treated group were 64%, 67% and 65% respectively, and the respective scores were lowered significantly after treatment. Compared with the control group, the difference between the two groups was statistically significant (P<0 01,P<0 05). Immunohistochemical test showed that WSC could inhibit the subgroups of intestinal metaplasia, CEA and PCNA expression significantly (P<0 01). Conclusion: WSC could significantly improve the clinical and pathological changes in the precancerous lesions of CAG. The mechanism might be related to the inducing and promoting effect of WSC on the differentiation and maturity of intestinal metaplasia cells and dysplasia cells. WSC could also inhibit and correct the abnormal proliferation of cells.

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