养血清癜汤治疗慢性特发性血小板减少性紫癜临床研究

目的：观察养血清癜汤治疗慢性特发性血小板减少性紫癜（ＩＴＰ）临床疗效，探讨可能的疗效机制。方法：设立养血清癜汤治疗组（简称治疗组）５５例和氨肽素对照组（简称对照组）２２例，用现代免疫学指标对疗效机制进行探讨。结果：治疗组显效率、良效率、总有效率分别为３２７％、２００％和８７３％；对照组为４５％、９１％和４５５％，两组比较有显著性差异（Ｐ＜００１）。治疗组无论在血小板恢复、出血症状改善还是在起效时间上均明显优于对照组（Ｐ＜００１）。各项免疫学检查显示：治疗前，ＩＴＰ患者体液免疫、细胞免疫及血小板功能异常；治疗后，治疗组ＩＴＰ患者体液免疫、细胞免疫及血小板功能恢复（Ｐ＜００５～０００１）。结论：养血清癜汤治疗ＩＴＰ临床疗效可靠，其疗效机制可能是通过对体液免疫的选择性抑制作用、对细胞免疫的双向调节作用和对血小板功能的恢复作用来实现的。

英文摘要:

Objective: To observe the clinical effect of treatment of chronic idiopathic thrombocytopenic purpura (CITP) by Decoction of Nourishing Blood and Eliminating Purpura (DNBEP), and study the possible mechanism. Methods: Effect of 55 patients of CITP in treatment group treated by DNBEP and 22 patients in the control group treated by Antaisu were observed and compared. Their immunologic indexes were determined for exploring the mechanism. Results: The markedly effective, improved and total effective rate of the treatment group were 32.7%, 20.0% and 87.3%, while those of the control group were 4.5%, 9.1% and 45.5% respectively, the difference between the two groups was significant (P<0 001). The effect of the treatment group was better than the control group in platelet count restoring, hemorrhagic symptoms improving and effect initiating, P<0 01. Immunologic test showed that the humoral and cell immune function as well as platelet function were abnormal in CITP patients. These functions were improved after treatment, and the effectiveness of the treatment group was significantly superior to that of the control group. Conclusions: DNBEP is reliable in treating CITP clinically. Its mechanism might be better due to its selective suppression of humoral immune function, bi directional regulation of cell immune function and recovery of platelet function.

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