中药肝豆片Ⅰ号与二巯基丁二酸治疗肝豆状核变性疗效的比较

作者	单位
韩咏竹	安徽中医学院神经病学研究所
何光远	安徽中医学院神经病学研究所
王训	安徽中医学院神经病学研究所
李凯	安徽中医学院神经病学研究所
王共强	安徽中医学院神经病学研究所
杨任民	安徽中医学院神经病学研究所

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中文摘要:

目的：观察比较中药肝豆片Ⅰ号与二巯基丁二酸胶囊（ＤＭＳＡ）治疗肝豆状核变性的疗效。方法：９４例患者随机分为两组，Ａ组３２例予肝豆片Ⅰ号治疗，Ｂ组６２例予ＤＭＳＡ治疗，两组均治疗４周。以改良Ｇｏｌｄｓｔｅｉｎ分级法作疗效判断。结果：Ａ组总有效率（７１９％）与Ｂ组（７７４％）相似（Ｐ＞００５）；但Ｂ组不良反应发生率高于Ａ组（Ｐ＜００１）。结论：肝豆片Ⅰ号低毒、高效，更适宜长期口服，用于治疗肝豆状核变性安全、有效。

英文摘要:

Objective: To compare the effects of Gandou Ⅰ (GD, a Chinese herbal preparation) and dimercaptosuccinate acid (DMSA) in treating Wilson disease (WD). Methods: Ninety four patients with WD were divided into 2 groups, 32 cases in the GD group and 62 in the DMSA group, they were treated with GD and DMSA respectively. The therapeutic course was 4 weeks for both groups. Modified Goldstein’s Degree was adopted to evaluate the clinical effect. Results: The total effective rate of the GD group was 71.9%, which was similar to that of the DMSA group (77.4%,P>0 05). But the adverse reaction occurred in the latter group was more than that in the former. Conclusion: GD is a low toxic and highly effective drug for long term treatment of WD.

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