雷公藤制剂副作用的临床观察

作者	单位
周嘉陵	上海光华中西医结合医院
朱琦	上海光华中西医结合医院
杨晓凌	上海光华中西医结合医院
张芳	上海光华中西医结合医院

摘要点击次数: 1616

全文下载次数: 1443

中文摘要:

目的：观察雷公藤制剂的副作用。方法：应用雷公藤制剂治疗类风湿关节炎（ＲＡ）患者２７１例，并观察其副作用发生情况。结果：雷公藤叶提取物雷诺酯片比雷公藤根提取物雷公藤片对生殖系统影响小。雷公藤根蕊提取物雷公藤多甙片在治疗ＲＡ中，每日６０ｍｇ大剂量比每日３０ｍｇ小剂量副作用发生率高（Ｐ＜００１）。＜５０岁女性患者主要副作用以月经失调为主；＞５０岁患者要注意对肾脏的影响。在长期应用中，雷公藤多甙片的副作用主要发生在前１０年。雷公藤多甙片应用在湿热瘀阻型ＲＡ比肝肾阴虚型ＲＡ副作用发生率低（Ｐ＜００５）。结论：雷诺酯片适用于青年女性患者。雷公藤多甙片小剂量适应维持治疗，而以治疗湿热瘀阻型患者为佳。

英文摘要:

Objective: To observe the side effects of Tripterygium preparation (TP) in the course of treatment. Methods: Two hundred and seventy one cases of patients with rheumatoid arthritis (RA) were treated using various TP to observe the occurrence of adverse reaction. Results: The influence on reproductive system with TP extracted from the leaf ester tab were less than that from the root (TP tab and TP multiglycoside tab, TPMG). In group of TPMG the rate of side effect of 60 mg daily dosage was more than 30 mg daily (P<0 01). The main influence on digestive tract and irregular manstruation was before age of 50 years and on renal function was after age of 50 years. Those adverse reactions mainly occur within first ten years in long therapy period. The side effects of TPMG produced in the Dampness Heat type of RA were lower than Yin Deficiency of Liver and Kidney type of RA (P<0 05). Conclusion: TP ester tab is available for young woman and TPMG tab is suitable for the Dampness Heat type of RA with lower dosis maintainance therapy.

关闭