| 周学平,周仲瑛,金妙文,郭立玮,方泰惠,汪红,许惠琴,吴勉华.舒关冲剂治疗中晚期类风湿性关节炎的临床与实验研究[J].中国中西医结合杂志,1999,(2):80-83 |
| 舒关冲剂治疗中晚期类风湿性关节炎的临床与实验研究 |
| Clinical and Experimental Study on Effect of Shuguan Granule on Mid Late Rheumatoid Arthritis |
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| DOI： |
| 中文关键词: 类风湿性关节炎 舒关温经冲剂 舒关清络冲剂 抗炎 免疫功能 |
| 英文关键词:rheumatoid arthritis Shuguan Wenjing granule Shuguan Qingluo granule anti inflammation immune function |
| 基金项目:国家中医药管理局青年基金 |
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| 中文摘要: |
| 目的：探讨舒关冲剂治疗类风湿性关节炎的作用机理。方法：以益肾蠲痹、消痰化瘀为基本治疗大法，研制了舒关温经冲剂与舒关清络冲剂，分别治疗中晚期类风湿性关节炎４４例（温经组）和４３例（清络组），并以痹冲剂为对照，还进行了动物实验研究。结果：临床总有效率：温经组为８８６％，清络组为９３０％，对照组为７３２％；两冲剂能明显提高弗氏完全佐剂关节炎大鼠血清ＳＯＤ水平，降低血清白介素１、血浆前列腺素Ｅ２和血栓烷Ｂ２的含量，与模型组比较有显著性差异（Ｐ＜００５，Ｐ＜００１）。结论：舒关冲剂具有抗炎镇痛、调节免疫紊乱、抗氧化、抗高凝等多种综合作用。 |
| 英文摘要: |
| Objective: To explore the therapeutic mechanism of Shuguan Granule (SGG) in treating mid late rhematoid arthritis. Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to remove stasis, two SGG, Shuguan Wenjing granule (SW) and Shuguan Qingluo granule (SQ) were prepared and used to treat mid late 44 and 43 patients of rheumatoid arthritis respectively. The clinical result was compared with that of Wangbi Granule. Animal experiments on the effect of the two SGG were conducted. Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant induced arthritis showed that the two SGG obviously raise the level of serum SOD, and lowered the levels of serum interleukin 1, plasma prostaglandin E 2 and thromboxane B 2, as compared with the model group, the difference was significant (P<0 05, P<0.01). Conclusion: The two SGG have a comprehensive function of anti inflammatory, analgesia, antioxidation, antihypercoagulation and immunoreglattion. |
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