中药治疗先兆流产对血浆β-内啡肽和胎盘内分泌的影响

目的：探讨中药治疗先兆流产时血浆β 内啡肽（β ＥＰ）和胎盘内分泌功能的变化。方法：采用补肾益气、止血安胎法治疗４０例有反复自然流产史的先兆流产患者，用放射免疫法测定血浆β ＥＰ及促性腺释放激素（ＧｎＲＨ）、人绒毛膜促性腺激素（ＨＣＧ）和孕酮（Ｐ４）水平，并选择正常早孕和不全流产患者作为对照。结果：先兆流产患者血浆β ＥＰ值明显高于正常妊娠相应孕周水平（Ｐ＜００１），ＧｎＲＨ、ＨＣＧ和Ｐ４则明显低于正常值（Ｐ＜００１）。经过中药治疗后，先兆流产症状消失，３６例患者足月分娩，其孕１０～１２周时上述４项测定值与相应正常孕周间无显著性差异。结论：中药治疗先兆流产有调节血浆β ＥＰ和胎盘内分泌的作用。

英文摘要:

Objective: To explore the effect of TCM on plasma β endorphin (β EP) and placental endocrine function in patients of threatened abortions (TA). Methods: Changes of plasma β EP, gonadotrophin releasing hormone (GnRH), human chorionic gonadotrophin (HCG), progesterone (P 4) levels were measured with RIA in 40 cases of TA with a history of recurrent spontaneous abortion treated with Chinese herbal medicine for reinforcing Kidney and Qi, hemostasis and antiabortion. And the results were compared with those of normal early pregnant women and patients with incomplete abortion as control. Results: The plasma β EP level in TA was significantly higher than that in normal pregnant women, P<0 01. On the contrary, plasma GnRH, HCG and P 4 were obviously lower in TA as compared with those of the normal cases, P<0 01. After treatment, 36 of the 40 patients succeeded in the continuity of pregnancy, their symptoms of TA disappeared, and the above mentioned four criteria measured at 10 12th week of gestation were similar to those of normal cases, P>0 05. Conclusion: TCM treatment can regulate plasma β EP and placental endocrine function in threatened abortion.

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