蠲哮片治疗哮喘的临床及实验研究

作者	单位
洪广祥	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006
张燕萍	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006
黄敬耀	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006
王伟	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006
马莉	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006
赵风达	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006
范希光	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006
陈建建	Hong Guangxiang, Zhang Yanping, Huang Jingyao, et al Jiangxi College of TCM, Nanchang (330006

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中文摘要:

目的：评价蠲哮片对支气管哮喘病的疗效。方法：４４７例支气管哮喘病患者，临床采用双盲或单盲对照，进行疗效及安全性临床观察，并进行平喘、祛痰、抗菌、耐缺氧等药理实验和急、慢性毒性实验。结果：临床观察蠲哮片的临床控制率为３８２％，显效率为３１２％，总有效率为９３４％；对照组（用牡荆油丸）分别为１３３％，２００％，６８５％。肺功能、ＩｇＥ等检测符合临床疗效。动物实验证实蠲哮片具有平喘、祛痰、抗菌、耐缺氧作用，其ＬＤ５０为（４０４８±５１７）ｇ／ｋｇ。结论：蠲哮片是临床治疗支气管哮喘的疗效好、毒副作用低的中药制剂。

英文摘要:

Objective: To evaluate the therapeutic effect of Juanxiao Tablet (JXT) in treating asthma. Methods: Clinical observation on 447 cases of asthma was done by double or single blind control method, and the therapeutic effect and safety of JXT were analysed. The effect of JXT in antiasthma, expectorant, antisepsis, hypoxia tolerance was studied, and its acute and chronic toxicity also examined. Results: The clinical control rate in patients treated with JXT was 38.2%, its markedly effective rate 31.2% and total effective rate 93.4%, while in patients treated with Oleum Vitex Negundo, the respective data were 13.3%, 20.0% and 68.5%. Results of pulmonary function and IgE measurement were consistent with clinical effect. Experimental study showed that the JXT has the action of anti asthma, expectorant, antisepsis and hypoxia tolerance enhancement, its LD 50 was (40 48±5.17)g/kg. Conclusion: JXT is a new Chinese herbal preparation of good effect, less toxic side reaction for asthma treatment.

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