止泻补液合剂治疗小儿腹泻合并脱水的临床与实验研究

作者	单位
朱锦善	Zhu Jinshan, Zhong Chengwei, Sun Dongliang, et al Shenzhen Children Hospital, Guangdong (518026
衷诚伟	Zhu Jinshan, Zhong Chengwei, Sun Dongliang, et al Shenzhen Children Hospital, Guangdong (518026
孙栋梁	Zhu Jinshan, Zhong Chengwei, Sun Dongliang, et al Shenzhen Children Hospital, Guangdong (518026
谭毓治	Zhu Jinshan, Zhong Chengwei, Sun Dongliang, et al Shenzhen Children Hospital, Guangdong (518026
喻闽凤	Zhu Jinshan, Zhong Chengwei, Sun Dongliang, et al Shenzhen Children Hospital, Guangdong (518026
殷明辉	Zhu Jinshan, Zhong Chengwei, Sun Dongliang, et al Shenzhen Children Hospital, Guangdong (518026

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中文摘要:

目的：观察止泻补液合剂治疗小儿腹泻合并轻、中度脱水的疗效。方法：应用止泻补液合剂与口服补液盐（ＯＲＳ）对照，治疗腹泻合并轻、中度脱水的患儿，观察临床疗效并进行实验研究。结果：临床研究结果显示，纠正脱水的疗效与对照组无显著性差异（Ｐ＞００５），而在止泻及消除其他症状（呕吐、腹胀）较对照组为优（Ｐ＜００１）。经检测止泻补液合剂的渗透压及钠、钾、氯、葡萄糖等离子浓度与ＯＲＳ相近，且口感好。动物实验结果显示：止泻补液合剂能显著抑制小鼠小肠运动、促进肠内水分吸收、促进因腹泻造成体重减轻的恢复，与ＯＲＳ比较，促进水分吸收无显著性差异（Ｐ＞００５），而止泻作用更为显著（Ｐ＜００１）。结论：止泻补液合剂是一种集补液、止泻功能于一体的新型制剂，优于ＯＲＳ，值得进一步开发和推广应用。

英文摘要:

Objective: To observe the therapeutic effect of Zhixie Buye mixture (ZXBYM) on infantile diarrhea patient with mild and middle degree of dehydration. Methods: The controlled observation method was adopted in the clinical and experimental study. Results: There was no significant difference in the treatment of dehydration between the ZXBYM group and ORS group (P>0 05), while it was more effective for ZXBYM to eliminate the symptoms such as vomiting and abdominal distension (P<0 01). In addition, it was confirmed that the ion concentration of sodium, potassium, chlorine, glucose and osmotic pressure in the mixture was similar to those in ORS. Animal experiment showed that it has the effect of rat intestine peristalsis suppression and water absorption promotion in colon for ZXBYM. And there was statistical difference in antidiarrhea effect between the mixture and ORS (P<0 01). Conclusion: The ZXBYM is an effective mixture in the treatment of diarrhea with dehydration. It has a good prospect of development and application.

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