清解凉利法治疗小儿急性肾炎的临床研究

目的：探讨一氧化氮（ＮＯ）与小儿急性肾炎发病关系及中西医结合治疗对其影响。方法：将４４例急性肾炎患儿分为两组，甲组采用凉利法加西药，乙组采用清解凉利法加西药。用Ｇｒｉｅｓ硝酸盐还原法进行治疗前后血亚硝酸／硝酸盐（ＮＯ－２／ＮＯ－３）测定，并以２８例健康儿童作对照。结果：急性期患儿ＮＯ－２／ＮＯ－３显著高于恢复期及对照组（Ｐ＜００１）。肉眼血尿ＮＯ－２／ＮＯ－３高于镜下血尿（Ｐ＜００１）。尿补体第三成分（Ｃ３）、α２－巨球蛋白（α２Ｍ）阳性者ＮＯ－２／ＮＯ－３高于阴性者（Ｐ＜００１）。伴感染者ＮＯ－２／ＮＯ－３高于无感染者（Ｐ＜００１）。近期治愈率乙组高于甲组（Ｐ＜００１）。结论：ＮＯ参与急性肾炎发病及病理损伤过程，清解凉利法加西药可抑制ＮＯ所致肾组织损伤，使病情缓解。

英文摘要:

Objective: To find out the relationship between nitric oxide and onset of infantile acute nephritis, and the effect of traditional Chinese medicine (TCM) and Western medicine (WM) combination therapy. Methods: Dividing 44 infantile acute nephritis patients into two groups. Group 1 was treated with cooling blood and diuretic principle, together with WM, Group 2 was treated with antipyretic and detoxication, cooling blood and diuretic principle, together with WM. The content of nitrite/nitrate iron (Fe NO 2/NO 3) in blood before and after treatment were determined through Griess nitrate reduction method, then compared with that of 28 healthy children. Results: The content of Fe NO 2/NO 3 being in acute nephritis period was obvious higher than that of control group and reconvalecent period, P<0 01. The macroscopic hematuria was higher than that of microscopic hematuria, P<0 01. Urinary alexin third element (C 3) and α 2 macroglobulin (α 2 M) positive patients Fe NO 2/NO 3 was higher than that of negative ones, P<0 01. Those complicated with infection Fe NO 2/NO 3 was higher than that without infection P<0 01. Short term cure rate of group 2 was higher than that of group 1, P<0 05. Nitric oxide may participate the onset and pathogenesis of infantile acute nephritis. Conclusion: $$$$ TCM WM combination therapy, especially antipyretic and detoxication, cooling blood and diuretic principle, could restrain nitric oxide from damaging tissue and remitting disease.

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