老年冠心病痰瘀辨证与血清脂蛋白谱检测的探讨

Exploring into Relationship between Serum Lipoprotein Electrophoretogram and the Differentiation as Phlegm Stasis Syndrome of Aged Coronary Heart Disease Patients

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DOI：

中文关键词: 老年血脂血清脂蛋白谱冠心病痰瘀辨证动态平衡

英文关键词:Aged blood lipid serum lipoprotein electrophoretogram coronary heart disease phlegm stasis syndrome differentiation dynamic balance

基金项目:广东省自然科学基金

作者	单位
张暋	Zhang Min, Liang Donghui, Zeng Zhaolong, et al The Zhujiang Hospital, The First Military Medical University of PLA, Guangzhou (510282
梁东辉	Zhang Min, Liang Donghui, Zeng Zhaolong, et al The Zhujiang Hospital, The First Military Medical University of PLA, Guangzhou (510282
曾昭龙	Zhang Min, Liang Donghui, Zeng Zhaolong, et al The Zhujiang Hospital, The First Military Medical University of PLA, Guangzhou (510282
李小敏	Zhang Min, Liang Donghui, Zeng Zhaolong, et al The Zhujiang Hospital, The First Military Medical University of PLA, Guangzhou (510282
陈允钦	Zhang Min, Liang Donghui, Zeng Zhaolong, et al The Zhujiang Hospital, The First Military Medical University of PLA, Guangzhou (510282
钱学贤	Zhang Min, Liang Donghui, Zeng Zhaolong, et al The Zhujiang Hospital, The First Military Medical University of PLA, Guangzhou (510282
尹炳生	Zhang Min, Liang Donghui, Zeng Zhaolong, et al The Zhujiang Hospital, The First Military Medical University of PLA, Guangzhou (510282

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中文摘要:

目的：本研究对确诊冠心病（ＣＨＤ）老年患者１７１例（行冠脉造影术者８１例）进行痰瘀辨证，观察５种证型与血清脂蛋白动态平衡紊乱的关系。方法：用改良双梯度聚丙烯酰胺凝胶电泳法检测血清脂蛋白谱（ＳＬＰＧ）和用酶法检测血清总胆固醇（ＴＣ）含量。结果：（１）与对照组比较，各夹证型间异常项数有显著性差异，血瘀型、痰瘀型、气滞血瘀型显著多于无夹证型和痰浊型，ＳＬＰＧ异常指数顺序是痰瘀型（１９４１）＞气滞血瘀型（１９０１）＞血瘀型（１６４３）＞痰浊型（１３５７）＞无夹证型（１１０５），而对照组仅为００５６。（２）冠脉造影阳性者６４例，其中ＳＬＰＧ阳性者５９例，占９２１９％；冠脉造影无异常发现者１７例，其中ＳＬＰＧ异常者１４例占８２３５％。（３）随着痰瘀夹证加重，ＴＣ含量有增加趋势，但均值都小于２１００ｍｇ／Ｌ，在临界水平以下。结论：对老年ＣＨＤ危险因素而言，ＴＣ不是一个理想的指标；ＳＬＰＧ是判断血清蛋白动态平衡的有效指标，和痰瘀辨证分型的诊断明显相关，对老年ＣＨＤ的诊治有重要价值。

英文摘要:

Objective: To observe the relationship between dynamic balance of the disturbance of serum lipoprotein and the 5 syndrome types during Phlegm stasis syndrome (PSS) differentiation. Methods: There were 171 patients, among them 81 cases were performed coronary arteriography (CAG). The serum lipoprotein electrophoretogram (SLPG) was examined by the double gradient polyacrylamide gel electrophoresis and the serum total cholesterol (TC) was determined with enzymatic method. Results: (1)Comparing the PSS with the control group, there was significant difference in the abnormal items (P<0 05～0.01). The blood stasis syndrome, PSS, and the Qi stagnation blood stasis syndrome were more than the phlegm syndrome and the non PSS ones. The abnormal index of SLP (SLPI) had the following order:PSS(SLPI 1.941)>Qi stagnation blood stasis syndrome (1.901)>blood stasis syndrome (1.643)>phlegm synrome (1.357)>non PSS(1.105) and >the control syndrome (0.056). (2)The positive cases in CAG was 64 patients, in SLPG, it was 59 cases (92.19%). The negative in CAG was 17 cases, but the positive in SLPG, it was 14 cases (82.35%). (3)As the PSS developed further, the TC had an increasing tendency, but their average was less than 2100mg/L, under the critical level. Conclusion: As the risk factor of the aged CHD, the TC was not an ideal criteria, the SPLG was an effective index. It was related with the PSS differentiation of the aged CHD.

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