清开灵注射液治疗急性上呼吸道感染的临床研究

作者	单位
李春生	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
王小沙	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
陈淑敏	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
袁彩芹	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
李晶	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
王晓明	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
姚沁	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
李鲤	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
郭会军	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
惠曼华	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091
赵卫国	Li Chunsheng, Wang Xiaosha, Chen Shumin, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091

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中文摘要:

目的：探讨清开灵注射液（简称清开灵）对急性发热的疗效。方法：每日采用清开灵１２０、１６０、２００ｍｌ３个剂量，并以洁霉素注射液（简称洁霉素）１８ｇ做对照，观察急性上呼吸道感染患者４００例的疗效。结果：清开灵愈显率８４１４％，洁霉素愈显率７５８３％，前者疗效优于后者（Ｐ＜００１）。清开灵（一次性常规剂量）降低体温平均起效时间（１２６ｈ）较洁霉素（１７６ｈ）短，清开灵对病程１天以内的患者，疗效优于病程３天者。但３个剂量之间，疗效无显著性差异（Ｐ＞００５）。清开灵各剂量组及总体降低白细胞总数的效果，均与洁霉素相仿。清开灵对咽拭子培养有致病菌生长者，体内抗菌作用很好。结论：清开灵是治疗急性上呼吸道感染的高效、速效药品

英文摘要:

Objective: To explore the effect of Qingkailing injection (QKLI) in treating acute fever, Methods: Four hundred cases of acute upper respiratory tract infection were divided into three groups treated with QKLI 120 ml/d, 160ml/d and 200 ml/d respectively, and compared with a control group treated with lincomycin 1.8g/d. Results: The markedly effective rate of QKLI was 84.14% which was better than that of lincomycin (75.83%) . The mean initial time of QKLI (12.6h) was shorter than that of lincomycin (17.6h). Effect of QKLI on patients with disease course within one day was better than that within 3 days. No significant difference revealed between effects in groups treated with different dosage of QKLI. The effect of QKLI in lowering white blood cell count was similar to that of lincomycin. For patients with positive throat swab culture of pathogenic bacteria, QKLI displayed good antibacterial action in vivo. Conclusion: QKLI is a highly effective with rapid action drug for treatment of acute respiratory infection.

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