黄芩甙、川芎嗪对兔百日咳菌液脑水肿与颅内高压的治疗作用

作者	单位
陈光福	Chen Guangfu, Yu Peilan, Jin Liming, et al Xiangya Hospital, Hunan Medical University, Changsha (410008
虞佩兰	Chen Guangfu, Yu Peilan, Jin Liming, et al Xiangya Hospital, Hunan Medical University, Changsha (410008
金立明	Chen Guangfu, Yu Peilan, Jin Liming, et al Xiangya Hospital, Hunan Medical University, Changsha (410008
杨于嘉	Chen Guangfu, Yu Peilan, Jin Liming, et al Xiangya Hospital, Hunan Medical University, Changsha (410008
刘运生	Chen Guangfu, Yu Peilan, Jin Liming, et al Xiangya Hospital, Hunan Medical University, Changsha (410008
陶永光	Chen Guangfu, Yu Peilan, Jin Liming, et al Xiangya Hospital, Hunan Medical University, Changsha (410008

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中文摘要:

目的：对比观察甘露醇（ＭＮ）、川芎嗪（ＴＭＰＺ）、黄芩甙（ＢＣ）等对兔百日咳菌液（ＰＢ）脑水肿与颅内高压的疗效。方法：动物分成５组，生理盐水组（ＮＳ组）、百日咳菌液未治疗组（ＰＢ组）、甘露醇治疗组（ＭＮ组）、川芎嗪治疗组（ＴＭＰＺ组）、黄芩甙治疗组（ＢＣ组），经左侧颈内动脉注入ＰＢ建立感染性脑水肿模型，采用光导纤维颅内压监测方法监测颅内压（ＩＣＰ），观察用药后４ｈ内ＩＣＰ变化及４ｈ脑组织含水量（ＷＣ）、伊文思蓝（ＥＢ）、Ｎａ＋、Ｋ＋含量与形态学改变。结果：ＭＮ、ＴＭＰＺ、ＢＣ三者均能降低ＰＢ导致的兔脑水肿与颅内高压（ＩＣＨ），ＭＮ组降低ＩＣＨ作用最迅速和最明显，但持续时间较短，２～４ｈ颅内压高于ＴＭＰＺ组和ＢＣ组，但仍低于ＰＢ组。ＴＭＰＺ组和ＢＣ组降ＩＣＨ作用较缓慢，但持续时间较长，且ＢＣ组３～４ｈ颅内压又低于ＴＭＰＺ组。在降低ＩＣＨ作用的同时，ＷＣ、ＥＢ含量、Ｎａ＋含量及病理形态改变均相应减轻。结论：ＢＣ与ＴＭＰＺ对感染性脑水肿颅内高压均具有治疗作用，ＢＣ的效果优于ＴＭＰＺ。

英文摘要:

Objective: To evaluate the effects of mannitol (MN), baicalin (BC) and tetramethylpyrazine (TMPZ) on intracranial hypertension (ICH) of infectious brain edema induced by Pertussis bacilli (PB) in rabbits. Methods: Forty five rabbits were divided randomly into five groups: the normal saline group (A); the pertussis bacilli group (B); the MN treated group (C); the TMPZ treated group (D) and the BC treated group (E). PB was injected into the left internal carotid artery of rabbits to establish the infectious brain edama model, their intracranial pressure (ICP) was monitored continuously by fiberoptic ICP monitor. Treatments were given intravenously 1 hour after injecting PB, and changes of ICP, brain water content (WC), Evans blue (EB), Na +, K + and morphology were observed within 4 hours after PB or NS injection. Results: MN, TMPZ and BC all could reduce the brain edema and ICH in rabbits induced by PB, the effect of MN was the most rapid and obvious one, but it lasted for rather shorter time, while the effect of TMPZ and BC was initiated later but lasted for a longer time. The ICP of Group C in 2nd to 4th hour was higher than that of Group D and Group E, but lower than that of Group B. The ICP of Group E in 3rd to 4th hour was lower than that of group D. At the same time of lowering ICP, brain WC, EB, Na + contents and pathologic morphologic change were also alleviated. Conclusion: Both BC and TMPZ could reduce ICP in infectious brain edema, the effect of BC was better than that of TMPZ.

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