中药对肝动脉栓塞化疗所致肝损害的疗效观察

作者	单位
刘城林	Liu Chenglin, Cai Yuecheng, Huang Zhengye, et al. Zhaoqing Municipal Hospital of TCM, Guangdong (526020
蔡悦成	Liu Chenglin, Cai Yuecheng, Huang Zhengye, et al. Zhaoqing Municipal Hospital of TCM, Guangdong (526020
黄政叶	Liu Chenglin, Cai Yuecheng, Huang Zhengye, et al. Zhaoqing Municipal Hospital of TCM, Guangdong (526020
古云林	Liu Chenglin, Cai Yuecheng, Huang Zhengye, et al. Zhaoqing Municipal Hospital of TCM, Guangdong (526020
刘瑞萍	Liu Chenglin, Cai Yuecheng, Huang Zhengye, et al. Zhaoqing Municipal Hospital of TCM, Guangdong (526020

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中文摘要:

目的：探讨中药对肝动脉栓塞化疗所致肝损害的治疗效果。方法：总结采用Ｓｅｌｄｉｎｇｅｒ′ｓ技术行肝动脉栓塞化疗１１０例，随机分为Ａ、Ｂ两组。Ａ组６０例为中药治疗组，以中药清肝解毒散结汤随症加减治疗；Ｂ组５０例为西药常规治疗组。观察两组肝功能变化、肝硬变发生率及加重率。结果：按Ｃｈｉｌｄ′ｓ肝功能分级标准，结果肝功能下降的总体发生率Ａ组为４６６７％、Ｂ组为６８００％，Ａ组低于Ｂ组（Ｐ＜００５）。肝硬变发生率及加重率：Ａ组分别为３５００％（７／２０例）、５０００％（２０／４０例）；Ｂ组分别为６５００％（１３／２０例）、７６６７％（２３／３０例），两组比较均有显著性差异（Ｐ＜００５）。结论：中药清肝解毒散结汤对肝动脉栓塞化疗所致肝损害有减轻和预防作用。

英文摘要:

Objective: To observe the effect of Chinese herbal medicine on hepatic artery chemoembolization caused liver damage. Methods: One hundred and ten patients, who received hepatic artery chemoembolization, were divided into two groups, 60 patients in the treated group were treated with Qinggan Jiedu Sanjie Decoction and the other 50 Patients in the control group treated with routine western medicine. The changes of liver function, cirrhosis incidence and exacerbation rate of both groups were observed. Results: The total liver function deterioration rate of the treated group, according to Child′s grading standard, was 46.67%, while that of the control group was 68.00%, the former was much lower than the latter (P<0 05). The cirrhosis incidence and exacerbation rate in the treated group were 35.00% (7/20) and 50.00% (20/40) respectively, while in the control group, they were 65.00% (13/20) and 76.67% (23/30) respectively. The difference between the two groups was also significant (P<0 05). Conclusion: Qinggan Jiedu Sanjie Decoction has some effect on alleviating and preventing hepatic damage caused by hepatic artery chemoembolization.

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