血府逐瘀液对血小板与内皮细胞功能的影响

作者	单位
李艳梅	Li Yanmei, Wang Zhong, Weng Jin, et al The First Affiliated Hospital, Tianjin TCM College, Tianjin (300193
汪钟	Li Yanmei, Wang Zhong, Weng Jin, et al The First Affiliated Hospital, Tianjin TCM College, Tianjin (300193
翁进	Li Yanmei, Wang Zhong, Weng Jin, et al The First Affiliated Hospital, Tianjin TCM College, Tianjin (300193
陈志勇	Li Yanmei, Wang Zhong, Weng Jin, et al The First Affiliated Hospital, Tianjin TCM College, Tianjin (300193
陈可冀	Li Yanmei, Wang Zhong, Weng Jin, et al The First Affiliated Hospital, Tianjin TCM College, Tianjin (300193
田菲	Li Yanmei, Wang Zhong, Weng Jin, et al The First Affiliated Hospital, Tianjin TCM College, Tianjin (300193

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中文摘要:

目的：研究血府逐瘀液对血小板与内皮细胞功能的影响。方法：将不同浓度血府逐瘀液与血小板和体外培养人脐带内皮细胞共同作用，用放射免疫方法测定血小板膜表面ＧＰⅡｂ／Ⅲａ复合物和人脐静脉内皮细胞表面血栓调节蛋白（ＴＭ）分子数。结果：血府逐瘀液（４０ｍｇ／ｍｌ，８０ｍｇ／ｍｌ）明显抑制二磷酸腺苷诱导的ＧＰⅡｂ／Ⅲａ复合物分子表达，与对照组比较有显著性差异（Ｐ＜００５，Ｐ＜００１），而血府逐瘀液对ＴＭ无明显影响。结论：血府逐瘀液通过阻断ＧＰⅡｂ／Ⅲａ复合物的暴露，可抑制ＡＤＰ对血小板的激活。

英文摘要:

Objective: To explore the effect of Xuefu Zhuyu Decoction (XFZYD) on function of platelet and endothelial cell. Methods: Through incubation of XFZYD, in different concentration, with platelet and human umbilical vein endothelial cell, the platelet membrane glycoprotein Ⅱb/Ⅲa complex and thrombomoduline (TM) of human umbilical vein endothelial cell were determined by radioimmunoassay. Results: XFZYD in 40 mg/ml or 80 mg/ml could obviously inhibit the adenosine diphosphate induced glycoprotein Ⅱb/Ⅲa molecular expression, as compared with the control group, the difference was significant (P<0 05,P<0 01), but it did not influence the TM level significantly. Conclusion: XFZYD could inhibit the adenosine diphosphate induced activation of platelet through blocking the exposure of glycoprotein Ⅱb/Ⅲa complex.

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