健乳灵治疗乳腺增生病临床和实验研究

作者	单位
黄霖	Huang Lin, Pan Chaoming, Luo Chongqian, et al Department of TCM, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou (510120
潘朝明	Huang Lin, Pan Chaoming, Luo Chongqian, et al Department of TCM, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou (510120
罗崇谦	Huang Lin, Pan Chaoming, Luo Chongqian, et al Department of TCM, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou (510120
文端成	Huang Lin, Pan Chaoming, Luo Chongqian, et al Department of TCM, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou (510120
黄月玲	Huang Lin, Pan Chaoming, Luo Chongqian, et al Department of TCM, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou (510120
韦永芳	Huang Lin, Pan Chaoming, Luo Chongqian, et al Department of TCM, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou (510120

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中文摘要:

目的：探讨健乳灵治疗乳腺增生病的疗效和对性激素的调节机理。方法：观察健乳灵治疗前后乳腺增生病的临床变化及血清性激素变化。动物实验通过病理、电镜、放射免疫（ＲＩＡ）等法观察健乳灵治疗乳腺增生病的疗效和性激素的变化。结果：健乳灵能治疗乳腺增生病，治疗组临床治愈率为７２５％，总有效率为９０８％，与对照组比较有显著性差异（Ｐ＜００１），而且有调节性激素水平的作用；雌二醇（Ｅ２）和垂体催乳素（ＰＲＬ）明显降低（均Ｐ＜００５）；而孕酮（Ｐ）和睾酮（Ｔ）则有回升（均Ｐ＜００５）；促卵泡成熟激素（ＦＳＨ）和促黄体生成素（ＬＨ）改变无显著性差异（均Ｐ＞００５）。健乳灵对实验性乳腺增生大鼠有明显防治作用，能调整大鼠体内的性激素分泌；对实验性乳腺增生大鼠的乳腺结构也有明显的改善作用（Ｐ＜００１）。结论：健乳灵治疗乳腺增生病有显著的临床疗效，并能调整机体内源性激素水平，改善乳腺慢性囊性增生的病变过程。

英文摘要:

Objective: To observe the therapeutic effect of Jianruling (JRL) on hyperplasia of mammary gland (HMG) and to explore its mechanism in regulating sex hormones. Methods: Clinical changes of HMG were observed and serum sex hormones measured before and after JRL treatment. In experimental study, the effect of JRL was estimated by using electron microscope, pathologic and radioimmunoassay. Results: JRL could not only cure HMG, but also regulate the sex hormone secretion both in HMG patients and in rats. Clinical study showed that the clinical cure rate was 72.5%, and the total effective rate was 90.8%, it demonstrated a significant difference in comparing with the control group, P<0 01. The estradiol and prolactin levels of patients lowered significantly after JRL treatment, P<0 05, while progestogen and testosterone increased significantly, P<0 05, but no significantly change of follicle stimulating hormone and luteinizing hormone was found. JRL showed marked effect in treating and preventing experimental HMG in rats, it could modulate the secretive function of sex hormone, and improve the construction of mammary gland. Conclusion: JRL has significant effect in treating HMG, it can adjust the endogenous sex hormone level, delay the development of chronic cystic hyperplasia of mammary gland.

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