膜荚黄芪茎叶总黄酮对小鼠细胞免疫功能的影响

作者	单位
焦艳	Jiao Yan, Wen Jie, Yu Xiaohong, et al Heilongjiang University of TCM, Harbin (150040
闻杰	Jiao Yan, Wen Jie, Yu Xiaohong, et al Heilongjiang University of TCM, Harbin (150040
于晓红	Jiao Yan, Wen Jie, Yu Xiaohong, et al Heilongjiang University of TCM, Harbin (150040
张德山	Jiao Yan, Wen Jie, Yu Xiaohong, et al Heilongjiang University of TCM, Harbin (150040

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中文摘要:

目的：研究黄芪茎叶总黄酮（ＦＡＭ）的免疫调节作用。方法：用单克隆抗体检测实验小鼠药物处理前后Ｔ细胞总数及亚群变化；用核素标记法测定ＬＡＫ细胞活性的变化。结果：ＦＭＡ能促进ＣｏｎＡ诱导的淋巴细胞增殖，增加Ｔ细胞总数并调整Ｔ细胞亚群紊乱；提高ｒＩＬ２所诱导的ＬＡＫ细胞活性。结论：ＦＡＭ对免疫功能低下小鼠具有免疫刺激和免疫调整作用，为临床应用提供了实验依据。

英文摘要:

Objective: To investigate the immune regulation of flavonoid of Astragalus membranaceus′s stem and leaves (FAM). Methods: Changes of total T cell count and subsets in mice were determined by monoclonal antibody assay before and after treatment with FAM, and the LAK activity was tested simultaneously by isotope technique. Results: FAM could promote the proliferation of lymphocytes induced by ConA, raise the T cell count and regulate the T cell subsets disorder, elevate the LAK activity induced by IL 2. Conclusion: FAM possesses the effect of immune stimulation and immune regulation in treating immunosuppressive mice. This study provides the experimental basis for clinical application of FAM.

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