益精提神法治疗多发性梗塞性痴呆的实验研究

作者	单位
徐浩	Xu Hao, Shao Nianfang, Zhang Meizeng, et al Shandong University of TCM, Jinan (250014
邵念方	Xu Hao, Shao Nianfang, Zhang Meizeng, et al Shandong University of TCM, Jinan (250014
张美增	Xu Hao, Shao Nianfang, Zhang Meizeng, et al Shandong University of TCM, Jinan (250014
叶向荣	Xu Hao, Shao Nianfang, Zhang Meizeng, et al Shandong University of TCM, Jinan (250014
胡维诚	Xu Hao, Shao Nianfang, Zhang Meizeng, et al Shandong University of TCM, Jinan (250014
杜艳芝	Xu Hao, Shao Nianfang, Zhang Meizeng, et al Shandong University of TCM, Jinan (250014
刘秀云	Xu Hao, Shao Nianfang, Zhang Meizeng, et al Shandong University of TCM, Jinan (250014

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中文摘要:

目的：探讨益精提神法治疗多发性梗塞性痴呆（ｍｕｌｔｉｉｎｆａｒｃｔｄｅｍｅｎｔｉａ，ＭＩＤ）的作用机理。方法：采用同种大鼠无菌自然干燥血凝块颈总动脉注射及跳台反射第１次跳下潜伏期为筛选指标，成功地建立了ＭＩＤ大鼠模型。在此基础上，观察益精提神法（采用益智胶囊）对其学习记忆能力、血清及脑组织丙二醛（ｍａｌｏｎｄｉａｌｄｅｈｙｄｅ，ＭＤＡ）含量及超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，ＳＯＤ）活力、脑组织单胺递质水平以及多发性脑梗塞大鼠脑组织形态结构的影响。结果：ＭＩＤ大鼠模型出现了明显的学习记忆障碍，其脑组织匀浆ＳＯＤ活力及部分脑区单胺递质水平显著下降，血清及脑组织ＭＤＡ含量显著升高。益精提神法可明显改善ＭＩＤ大鼠学习记忆能力，升高脑组织ＳＯＤ活力及部分脑区单胺递质含量，降低血清及脑组织ＭＤＡ含量，对多发性脑梗塞大鼠脑组织形态结构具有保护作用。结论：益精提神法治疗ＭＩＤ的作用机理可能与其抑制脂质过氧化、影响脑组织部分脑区单胺递质水平及减轻脑组织缺血损伤等作用有关。

英文摘要:

Objective: To explore the mechanism of multi infarct dementia (MID) treated with reinforcing essence to refresh mental activity method (RERM). Methods: MID rat models were established by injecting sterile dry blood clots into common carotid artery and screening by the first jumping off latency of diving platform reflex. Effect of RERM on model rats in learning, memory, serum and brain malondialdehyde (MDA), superoxide dismutase (SOD) level, brain monoamine neurotransmitter content, and brain morphosis were observed. Results: Obvious malfunction of learning and memory was found in MID rat models, and there were also significant decreasing of monoamine neurotransmitters content in partial brain zones, decreasing of SOD activity in brain and increasing of MDA content in serum and brain. RERM could obviously improve learning and memory, raise SOD activity and monoamine neurotransmitters content in brain tissue, lower MDA content in serum and brain of MID rat models, protect brain morphosis of multi infarction rats. Conclusion: RERM might treat MID by restraining lipid peroxidation, improving monoamine neurotransmitters content in partial brain zones and decreasing ischemic damage of brain tissue.

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