藿丹片治疗小儿病毒性心肌炎的临床与实验研究

作者	单位
李谦	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
陈光喜	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
魏佑莲	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
吴锦	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
王美若	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
牛文琪	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
于芝坤	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
赵成莉	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003
张欣	Li Qian, Chen Guangxi, Wei Youlian, et al Affiliated Hospital of Shanxi Provincial Academy of Traditional Chinese Medicine, Xi′an (710003

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中文摘要:

目的：探讨藿丹片（原名心肌片）治疗小儿病毒性心肌炎的临床疗效及治疗机理。方法：采用藿丹片治疗３００例（治疗组）并与复方丹参片１２０例（对照组）治疗的方法作比较，疗程均为４周。结果：治疗组痊愈率２１３３％，显效率４６６７％，总有效率９１６７％，与对照组对比，无论愈显率、总有效率，体征消失及心电图改善均明显优于对照组。实验研究结果证明：藿丹片可改善心脏功能，明显改善微循环。细胞病变抑制法证明对柯萨奇病毒Ｂ３有非常显著的抑制作用，又动物模型证明对柯萨奇病毒性心肌炎具有减轻病理损害，促进治疗作用。急性毒性及长期毒性试验表明临床用药量是安全的。结论：藿丹片治疗机理：（１）对柯萨奇病毒性心肌炎具有减轻病理损害，促进治疗作用；（２）对病理改变的心肌细胞有促进供氧及减少耗氧作用；（３）明显增强免疫功能从而达到治愈及控制复发

英文摘要:

Objective: To study the effect of Huodan Tablet in treating pediatric viral myocarditis. Methods: Clinical manifestations and physical signs as well as laboratory examinations have been observed. Results: The markedly effective rate was 68%, the total effective rate was 91.67% in therapeutic group, while in control group, the markedly effective rate was 30.83% and the total effective rate 70.84%. According to Ridit analysis, significant difference was shown between the two groups. r therapeutic group=0.5000, r control group = 0.295 +2×0.025, respectively. Conclusion: Huodan Tablet has no toxic and side effect and can be taken safely and conveniently, it complies with the demands of WHO on new drug for prevention and cure of myocarditis.

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