筋脉通治疗糖尿病周围神经病变的临床观察

作者	单位
梁晓春	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
崔丽英	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
郭赛珊	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
张克俭	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
郝炜欣	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
贾力	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
张宏	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
孙仁宇	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
李本红	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730
杜红	Liang Xiaochun, Cui Liying, Guo Saishan, et al Peking Union Medical Hospital, Chinese Academy of Medical Seiences, Beijing (100730

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中文摘要:

目的 :观察中药筋脉通治疗糖尿病周围神经病变 (diabeticperipheralneuropathy ,DN)的临床疗效并探讨其作用机理。方法 :检测 2 8名健康人和 66例DN患者的红细胞醛糖还原酶活性 (redbloodcellaldolsereductaseactivity ,RBC -AR)和红细胞山梨醇 (redbloodcellsorbitol,RBC -S)等指标的变化。并随机将 66例DN患者分为筋脉通治疗组和金匮肾气治疗组 (各 33例 )观察其对RBC -AR活性、RBC -S浓度、神经传导速度等指标的影响。结果 :DN患者RBC -AR活性和RBC -S浓度明显高于健康人。用筋脉通治疗后RBC -AR活性和RBC -S浓度明显下降 ,神经传导速度增快 (P <0 0 5 ,P <0 0 1) ,在某些神经传导速度及波幅的改善方面优于金匮肾气治疗组。结论 :筋脉通能够减轻DN患者临床症状 ,改善病变神经传导速度 ,降低醛糖还原酶活性 ,减轻红细胞山梨醇的蓄积 ,对防治糖尿病神经病变有较好的疗效。

英文摘要:

Objective: To verify the effect of Jinmaitong composita (JMTC) on red blood cell aldolase reductase activity (RBC AR), RBC sorbitol (RBC-S) and nerve conductive velocity in diabetic peripheral neuropathy (DN). Methods: Sixty six patients with DN were divided randomly into two groups, 33 patients in treated group treated with JMTC and 33 cases in the control group treated with Jinkui Shenqi (JKSQ), RBC-AR, RBC-S and nerve transmission speed were observed before and after three months treatment. Results: Level of RBC-AR, RBC-S apparently decreased and nerve conductive velocity increased (P<0 05,P<0 01) after TMTC treatment. Conclusion: JMTC was able to improve the nerve conduction significantly with a lowering of RBC-AR and RBC-S and has good result in treating Diabetic peripheral neurophathy.

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