糖肾合剂治疗糖尿病肾病的临床观察

作者	单位
余宗阳	Yu Zongyang, Zhuang Yongze, Dai Xihu, et al Fuzhou General Hospital of Nanjing Military Region, Fuzhou (350025
庄永泽	Yu Zongyang, Zhuang Yongze, Dai Xihu, et al Fuzhou General Hospital of Nanjing Military Region, Fuzhou (350025
戴西湖	Yu Zongyang, Zhuang Yongze, Dai Xihu, et al Fuzhou General Hospital of Nanjing Military Region, Fuzhou (350025
刘建华	Yu Zongyang, Zhuang Yongze, Dai Xihu, et al Fuzhou General Hospital of Nanjing Military Region, Fuzhou (350025
赖玉链	Yu Zongyang, Zhuang Yongze, Dai Xihu, et al Fuzhou General Hospital of Nanjing Military Region, Fuzhou (350025

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中文摘要:

目的 :观察中药复方糖肾合剂对糖尿病肾病患者血糖、尿白蛋白定量、高凝状态及氧化损伤的影响。方法 :93例糖尿病肾病患者随机分为两组 ,通过糖肾合剂及胰岛素联合 (治疗组 )治疗与单纯用胰岛素 (对照组 )治疗的比较观察 ,评价糖肾合剂对糖尿病肾病患者空腹血糖 (FBG)、餐后 2h血糖 (PBG)、2 4h尿白蛋白、内皮素 (ET)、α 颗粒膜蛋白 14 0 (GMP - 14 0 )、红细胞超氧化物歧化酶 (ESOD)、过氧化脂质 (LPO)的影响。结果 :治疗组 2 4h尿白蛋白、ET、GMP - 14 0、LPO明显下降 ,ESOD活性显著升高 ,与治疗前比较有显著性差异 (P <0 0 1,P <0 0 5 )。对照组上述变化不明显。结论 :糖肾合剂能改善糖尿病肾病高凝状态 ,减轻肾脏自由基代谢紊乱 ,降低尿蛋白含量

英文摘要:

To investigate the effects of Tangshen Mixture (TSM) on the serum glucose, quantity of proteinuria per 24h, hypercoagulative status and oxidative injury in patients with diabetic nephropathy (DN). Methods: Ninety three patients with DN were randomly divided into treated group and control group. 48 patients in the former were treated with insulin and TSM, while the latter was treated with insulin alone. Before and after treatment, the levels of fasting blood glucose (FBG), 2h after meal blood glucose (PBG), 24h urinary albumin (24h pro), endothelin (ET), α granule membrane glycoprotein 140 (GMP 140), erythrocyte superoxide dismutase (ESOD), lipid peroxidase (LPO) were measured. Results: After two months treatment, compared with the control group the levels of ET and GMP 140, LPO, and 24h pro lowered obviously (P<0 01, P<0 05), and the level of ESOD increased (P<0 05) in the treated group. no obvious change was found in confrol grout after freatment. Conclusion: TSM could improve the hypercoagulative status, alleviate the renal free radical disturbances, and reduce the urinary protein loss.

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