2型糖尿病血瘀证患者血小板CD<sub>62p</sub>、CD<sub>63</sub>测定意义探讨

作者	单位
姜兆顺	Jiang Zhaoshun, Zhang Shenglan, Kou Tianqin, et al General Hospital of Jinan Military Region, Jinan (250031
张胜兰	Jiang Zhaoshun, Zhang Shenglan, Kou Tianqin, et al General Hospital of Jinan Military Region, Jinan (250031
寇天芹	Jiang Zhaoshun, Zhang Shenglan, Kou Tianqin, et al General Hospital of Jinan Military Region, Jinan (250031
邢万佳	Jiang Zhaoshun, Zhang Shenglan, Kou Tianqin, et al General Hospital of Jinan Military Region, Jinan (250031
晏辉	Jiang Zhaoshun, Zhang Shenglan, Kou Tianqin, et al General Hospital of Jinan Military Region, Jinan (250031
尹格平	Jiang Zhaoshun, Zhang Shenglan, Kou Tianqin, et al General Hospital of Jinan Military Region, Jinan (250031

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中文摘要:

内容提要　目的 :研究 2型糖尿病患者的血小板活化与血瘀证的关系及其影响因素。方法 :用单克隆抗体作分子探针 ,经流式细胞术测定了 30例 2型糖尿病血瘀证患者、2 7例 2型糖尿病非血瘀证患者及 2 0名健康者的血小板膜糖蛋白CD62p、CD63表达。结果 :2型糖尿病血瘀证组CD62p、CD63显著高于非血瘀证组及对照组 (P <0 0 0 1) ,血瘀证组CD62 p与CD63呈正相关 (r =0 73,P <0 0 1)、CD62 p与糖化血红蛋白 (HbA1c)、低密度脂蛋白胆固醇 (LDL -C)呈正相关 (r =0 43,r=0 45 ;P <0 0 5 )。结论 :2型糖尿病血瘀证患者血小板活化水平升高 ,它是血瘀证的重要分子学基础。说明了对 2型糖尿病患者进行血瘀辨证及活血化瘀治疗的重要性

英文摘要:

To study the relationship between blood stasis and platelet activation and the influential factors on the latter in type 2 diabetes mellitus (DM) patients. Methods: Platelet CD 62p , CD 63 expressions were determined in 30 patients of type 2 DM with blood stasis, 27 patients of type 2 DM without blood stasis and 20 normal controls by flow cytometry. Results: CD 62p , CD 63 levels were significantly higher in type 2 DM with blood stasis group than that without blood stasis group and in normal controls. CD 62p was positively correlated with CD 63 , while positive correlation existed between HbA lc, LDL C and CD 62p in DM patients with blood stasis. Conclusion: The increased level of platelet activation was the primary molecular basis in type 2 DM. It was important to perform the Syndrome Differentiation of blood stasis and treatment of activating blood circulation to remove blood stasis in type 2 DM.

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