补肾活血液对去势雌鼠骨质疏松的影响

作者	单位
张荣华	Zhang Ronghua, Chen Keji, Lu Daxiang, et al The First Affiliated Hospital of Medical College, Jinan University, Guangzhou (510630
陈可冀	Zhang Ronghua, Chen Keji, Lu Daxiang, et al The First Affiliated Hospital of Medical College, Jinan University, Guangzhou (510630
陆大祥	Zhang Ronghua, Chen Keji, Lu Daxiang, et al The First Affiliated Hospital of Medical College, Jinan University, Guangzhou (510630
侯励	Zhang Ronghua, Chen Keji, Lu Daxiang, et al The First Affiliated Hospital of Medical College, Jinan University, Guangzhou (510630

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中文摘要:

目的 :研究补肾活血液对模型大鼠骨质疏松的影响及其机制 ,为临床中医药治疗骨质疏松提供实验依据。方法 :SD雌性大鼠 5 0只 ,随机分为 5组 :正常组 ,模型加生理盐水组 ,雌激素组 ,中药高、低剂量组。采用切除卵巢诱导的骨质疏松模型 ,用灌胃法给服补肾活血液 ,并以尼尔雌醇及生理盐水作为对照。各组动物均在 12周后处死 ,测定尿总羟脯氨酸 (U Hyp)、尿肌苷 (U Cr)、骨钙素 (BGP)、股骨抗弯强度(FBS) ,处死前测定全身骨密度 (GBMD)。结果 :中药组的GBMD及FBS明显高于模型组 (P <0 0 5 ) ,但低于正常组 (P <0 0 5 ) ;BGP明显高于模型组 (P <0 0 5 ,P <0 0 1) ,在高剂量时接近正常组 ;U Hyp/Cr明显低于模型组 (P <0 0 5 ) ,但仍然高于正常组 (P <0 0 5 )。结论 :补肾活血液对模型鼠骨质疏松有明显的抑制作用 ,主要影响骨形成环节。

英文摘要:

Objective: To investigate the efficacy of Chinese recipe of replenishing Kidney and activating blood circulation (RKABC) in female rats with osteoporosis induced by ovariectomy. Methods: Fifty female SD rats at 12 months of age were chosen, and were divided into 5 groups: control, model, model plus nylestriol, RKABC (high dose) and RKABC (low dose). The model of osteoporosis was established by ovariectomy in rats for 12 weeks, and then was given different kinds of liquid and administered approximately for 12 weeks. General bone mineral density (GBMD), femur bending strength (FBS), serum BGP and urine Hyp/Cr were measured. Results: GMBD, FBS in 3 treatment groups were significantly higher than those in the model group (P<0 05), but lower than those in the normal control group (P<0 05); GBMD, FBS in 2 RKABC groups were slightly higher than those in nylestriol′s group (P>0 05). Compared with model group, levels of serum BGP in 2 RKABC groups increased (P<0 05) and in RKABC (H) treatment group increased almost the same as those in the control group (P>0 05). In comparison with model group, levels of U Hyp/Cr in 3 treatment groups decreased (P<0 05, PP<0.01) but 2 RKABC treatment groups still significantly higher than those in the normal control group (P<0 05). Conclusion: It indicated that RKABC could control osteoporosis in female rats induced by ovariectomy and seems to promote bone formation.

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