葛根素对冠心病患者纤溶功能及过氧化脂质的影响

作者	单位
陈江斌	湖北医科大学附属第一医院心血管内科!武汉430060
许家俐	湖北医科大学附属第一医院心血管内科!武汉430060
李建军	湖北医科大学附属第一医院心血管内科!武汉430060
黄从新	湖北医科大学附属第一医院心血管内科!武汉430060
唐其柱	湖北医科大学附属第一医院心血管内科!武汉430060
王晋明	湖北医科大学附属第一医院心血管内科!武汉430060
李庚山	湖北医科大学附属第一医院心血管内科!武汉430060

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中文摘要:

目的:观察葛根素对冠心病患者血清超氧化物歧化酶(SOD)、过氧化脂质(LPO)、组织型纤维蛋白溶酶原激活物(TPA)及组织型纤维蛋白溶酶原激活物抑制剂(PAI1)的影响。方法:将48例患者分成葛根素治疗组和对照组,葛根素治疗组用葛根素注射液600mg加入250ml液体中静脉滴注,每天1次,共1周,余治疗同对照组。用亚硝酸盐比色测定血清SOD活力,放射免疫法测定血清SOD含量,TBA荧光显色法测定血清LPO含量,纤溶酶特异性的发色底物分解显色法测定TPA和PAI1的活性。结果:用葛根素治疗组血清SOD活力明显增高(P<001),LPO含量降低(P<001),对照组SOD活力及LPO含量用药前后无明显改变(P>005);血清SOD的含量治疗组用药前后和对照组比较皆无明显差异(P>005);治疗组TPA、PAI1明显升高(P<001),而对照组治疗前后无明显变化(P>005)。结论:葛根素能升高冠心病患者SOD活力、降低LPO含量、提高纤溶功能。

英文摘要:

To observe the effect of puerarin on superoxide dismutase (SOD), lipid peroxidation (LPO), tissue plasminogen (TPA) and plasminogen activator inhibitor (PAI 1) of coronary heart disease (CHD) patients. Methods: Forty eight patients were divided into two groups (treated group and control group). Treated group was given intravenously 600 mg puerarin, once daily for one week, also the same treatment as that of control was given. Nitrite colorimetric method, radioimmunoassay (RIA), TBA fluorescent development process and fibrinolysin specific colorbase substrate decomposition development process were used to determine SOD activity, SOD, LPO, TPA and PAI 1. Results: After the treatment with puerarin, SOD activity was increased, LPO reduced, while without any changes in the control group. There was insignificant changes of SOD between the treated and the control groups. TPA and PAI 1 were increased significantly in the treated group, but was insignificantly changed in the control group. Conclusion: Puerarin can increase the SOD activity, decrease LPO level and enhance the activity of fibrinolysis.

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