王展翔,麻柔,郑金福,杨经敏,刘锋,许勇钢,杨留,胡乃平,王忠芬,胡晓梅,李柳,王天恩,周霭祥.扶正祛邪丹治疗骨髓增生异常综合征的临床及实验研究[J].中国中西医结合杂志,1999,(11):664-667 |
扶正祛邪丹治疗骨髓增生异常综合征的临床及实验研究 |
Clinical and Experimental Study on the Treatment of Myelodysplastic Syndromes with Fuzheng Quxie Tablet |
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DOI: |
中文关键词: 扶正祛邪丹 骨髓增生异常综合征 骨髓红系造血干细胞 |
英文关键词:Fuzheng Quxie Tablet myelodysplastic syndromes colony forming unit erythrocyte |
基金项目:国家中医药管理局青年基金!No .930 4 3 |
作者 | 单位 | 王展翔 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 麻柔 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 郑金福 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 杨经敏 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 刘锋 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 许勇钢 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 杨留 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 胡乃平 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 王忠芬 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 胡晓梅 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 李柳 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 王天恩 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 | 周霭祥 | Wang Zhanxiang, Ma Rou, Zheng Jinfu, et al Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091 |
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中文摘要: |
目的:研究扶正祛邪丹对骨髓增生异常综合征(MDS)的疗效与作用机理。方法:用扶正祛邪丹为主治疗MDS患者33例,观察血象、骨髓象、骨髓病理切片及免疫学的变化;用干细胞培养法观察扶正祛邪丹对BALB/C小鼠骨髓造血干细胞增殖的影响。结果:临床患者基本缓解率2424%,总有效率7272%。实验研究发现扶正祛邪丹对骨髓红系造血干细胞有明显促进作用。结论:扶正祛邪丹对MDS的难治性贫血疗效较好,可能是通过促进红系造血干细胞增殖实现的。 |
英文摘要: |
To study the mechanism of Fuzheng Quxie Tablet (FZQXT) in treating myelodysplastic syndromes (MDS). Methods: Thirty three cases of MDS were treated with FZQXT, changes of peripheral blood cells, morphology of bone marrow smear, bone marrow pathology and immunology were monitored before and after treatment. The effects of FZQXT on hematopoietic stem cells of mice were also observed. Results: The remission rate and total effective rate were 24.24% and 72.72% respectively. FZQXT had obvious effect in promoting the proliferation of colony forming unit erythrocytes (CFU E). Conclusion: The beneficial effect of FZQXT in treating refractory anemia might be reached through promoting the proliferation of erythrocytic hematopoietic stem cells. |
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