骨愈宝促进家兔肾虚骨折愈合的实验研究

作者	单位
郭建刚	Guo Jian′ gang, Mao Shuge, Zhao Ran, et al Luoyang Institute of Orthopedics and Traumatology, Henan (471002
毛书歌	Guo Jian′ gang, Mao Shuge, Zhao Ran, et al Luoyang Institute of Orthopedics and Traumatology, Henan (471002
赵然	Guo Jian′ gang, Mao Shuge, Zhao Ran, et al Luoyang Institute of Orthopedics and Traumatology, Henan (471002
侯桂英	Guo Jian′ gang, Mao Shuge, Zhao Ran, et al Luoyang Institute of Orthopedics and Traumatology, Henan (471002
马青雯	Guo Jian′ gang, Mao Shuge, Zhao Ran, et al Luoyang Institute of Orthopedics and Traumatology, Henan (471002
周英杰	Guo Jian′ gang, Mao Shuge, Zhao Ran, et al Luoyang Institute of Orthopedics and Traumatology, Henan (471002
张朝辉	Guo Jian′ gang, Mao Shuge, Zhao Ran, et al Luoyang Institute of Orthopedics and Traumatology, Henan (471002

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中文摘要:

目的:研究骨愈宝对家兔肾虚骨折愈合的影响。方法:用57只家兔随机分为空白组(A)、对照组(B)和实验组(C),剥离骨膜后,锯除桡骨中段073cm造双侧桡骨中段缺损,术后1周开始药物干扰治疗:A组常规喂养;B组常规喂养加强的松片6mg/(kg·d);C组喂加有骨愈宝的饲料加强的松片6mg/(kg·d),观察动物一般状态,体重变化,用药后3、6周分二批处死,取双前肢桡骨作X线及组织学检查。结果:A组无肾虚表现,B组逐渐产生肾虚,C组出现肾虚表现轻并很快纠正;骨缺损愈合程度,C组最好,A组次之,B组最差。结论:骨愈宝有纠正肾虚促进骨折愈合的作用。

英文摘要:

To study the effect of Guyubao (GYB) in promoting the fracture healing of Kidney deficiency (KD) rabbits. Methods: Fifty seven rabbits were randomly divided into three groups: The blank group (A), the control group (B) and the experimental group (C). After the periosteum was peeled off, 0.73cm middle section defects on both radius were removed. One week after operation, the experiment was begun: Group A was fed normally; group B fed normally plus 6mg/(kg·d) prednisolone; group C fed with food mixed with GYB and 6 mg/(kg·d) prednisolone. The general state and body weight were observed. The rabbits were sacrificed at three and six weeks after the beginning of experiment. Both radius were observed with X ray and histologic examination. Results: In group A, no KD appeared, group B gradually developed KD, and mild KD appeared in group C but adjusted rapidly. The healing of radial defect in order were C, A, B from higher to lower degree. Conclusion: The results revealed that the GYB could correct the KD and promote fracture healing.

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