右归饮、四君子汤、桃红四物汤调节肾虚、脾虚、血瘀证患者免疫功能的观察

作者	单位
许得盛	Xu Desheng, Shen Ziyin, Wang Wenjian, et al Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040
沈自尹	Xu Desheng, Shen Ziyin, Wang Wenjian, et al Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040
王文健	Xu Desheng, Shen Ziyin, Wang Wenjian, et al Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040
陈伟华	Xu Desheng, Shen Ziyin, Wang Wenjian, et al Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040
应健	Xu Desheng, Shen Ziyin, Wang Wenjian, et al Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040
何瑞瑾	Xu Desheng, Shen Ziyin, Wang Wenjian, et al Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040
鲁珊妹	Xu Desheng, Shen Ziyin, Wang Wenjian, et al Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040

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中文摘要:

目的:探讨右归饮、四君子汤、桃红四物汤对肾虚、脾虚、血瘀证患者免疫调节的不同作用。方法:用右归饮、四君子汤、桃红四物汤分别治疗肾虚、脾虚、血瘀证患者各40例,另分别设各证型20例予安慰剂作对照,观察治疗前后免疫功能情况。结果:四君子汤使脾虚患者、右归饮使肾虚患者的循环免疫复合物(CIC)水平下降(P<001),淋巴细胞转化率(淋转率)和自然杀伤(NK)细胞活性提高(P<001),四君子汤还使脾虚患者的IL2水平和嗜中性细胞吞噬指数提高(P<005);桃红四物汤使血瘀证患者CIC水平降低(P<001)的同时,提高了NK细胞活性(P<005)。结论:四君子汤、右归饮可明显提高脾虚证、肾虚证患者的免疫功能,特别是细胞免疫功能,尤以四君汤作用更全面显著。桃红四物汤消除免疫复合物的作用较为明显。

英文摘要:

Objective: To study the different immunoregulatory effects of Youguiyin, Sijunzitang, Taohong Siwutang to patients with deficiency of Kidney, Spleen and blood stasis Syndrome respectively. Methods: The treated group, 40 patients in each with deficiency of Kidney, Spleen and blood stasis were treated with Youguiyin, Sijunzitang and Taohong Siwutang respectively. Three control groups (20 patients each) were established respectively. Peripheral venous level of complement C 3, circulating immunocomplex (CIC), interleukin 2 (IL 2), interferon γ (IFN γ), lymphocyte transformation rate (LTR), the activity of natural killer (NK) cell, and the phagocytic function of neutrophil were measured before and after treatment. Results: Sijunzitang could reduce the level of CIC (P<0 01), raise the activity of NK cell and LRT (P<0 01) of the patients with deficiency of Spleen syndrome; the same did the Youguiyin to that of patients with deficiency of Kidney syndrome. Also, Sijunzitang could increase the level of IL 2 in blood and the phagocytic function of neutrophil (P<0 05); the Taohong Siwutang could lower the level of CIC to patients with blood stasis syndrome (P<0 01), increase the activity of NK cells (P<0 05). Conclusion: Youguiyin, Sijunzitang could enhance the immunoregulatory function of the patients with deficiency of Spleen and Kidney, particularly the cellular immune functions, in which the Sijunzitang effect is more complete and significant, while Taohong Siwutang eliminated the effect of CIC in blood better.

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