| 朱辟疆,韦先进,赵卫兵,赵华,田军民,邱建军.保元强肾Ⅱ号胶囊对慢性肾功能衰竭肾小管间质损伤的临床研究[J].中国中西医结合杂志,1999,(12):721-724 |
| 保元强肾Ⅱ号胶囊对慢性肾功能衰竭肾小管间质损伤的临床研究 |
| Effect of Baoyuan Qiangshen Capsule No. Ⅱ on Tubular Interstitial Injury in Chronic Renal Failure Patients |
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| DOI： |
| 中文关键词: 保元强肾Ⅱ号胶囊 慢性肾功能衰竭 视黄醇结合蛋白 β2-微球蛋白 N-乙酰氨基葡萄糖苷酶 Tamm-Horfau蛋白 |
| 英文关键词:Baoyuan Qiangshen Capsule No. Ⅱ chronic renal failure urine retinol binding protein β 2 microglobulin N acetyl β D glucosamindase Tamm Horfau protein |
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| 中文摘要: |
| 目的:探讨中药保元强肾Ⅱ号胶囊对慢性肾功能衰竭(CRF)的疗效及机理。方法:60例CRF患者随机分为保元强肾Ⅱ号胶囊加洛汀新组(治疗组,30例)及必需氨基酸加洛汀新组(对照组,30例),观察肾功能及肾小管标志蛋白的改变。结果:治疗组显效率及总有效率分别为633%及933%;对照组分别为300%及567%,治疗组疗效明显优于对照组(P<001);治疗组治疗后BUN、SCr及CCr均较治前明显改善,尿视黄醇结合蛋白、尿β2微球蛋白及尿N乙酰氨基葡萄糖苷酶均比治疗前显著降低,TammHorfau蛋白比治疗前显著增高(P<001或P<005)。结论:保元强肾Ⅱ号胶囊对肾小管间质损伤有明显的改善作用,从而改善肾功能,提高疗效。 |
| 英文摘要: |
| Objective: To investigate the protective effect and mechanism of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) in treating chronic renal failure (CRF). Methods: Sixty patients of CRF were divided into 2 groups randomly, the tested group treated with BYQS combined with Lotensin and the control group treated with essential amino acid combined with Lotensin. Changes of renal function and tubular marked proteins were observed. Results: The markedly effective rate and total effective rate of the tested group were 63.3% and 93.3% respectively and those of the control group were 30.0% and 56.7% respectively, the effect of the tested group was markedly better than that of the control group (P<0 01). In the tested group after treatment, BUN, SCr and CCr were improved significantly, urine retinol binding protein and β 2 microglobulin and N acetyl β D glucosamindase decreased significantly (P<0 01), while Tamm Horfau protein increased significantly (P<0 05). Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF. |
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