清胃泻火养阴法治疗复发性口疮的临床及实验研究

Clinical and Experimental Studies on Clearing Away Stomach Heat Purging Fire and Nourishing Yin Principle in Treating Patients of Recurrent Aphthae

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DOI：

中文关键词: 清胃泻火养阴口疮平冲剂复发性口疮免疫球蛋白 T淋巴细胞亚群迟发性超敏反应消炎抗渗

英文关键词:clearing away Stomach Heat purging Fire and nourishing Yin principle Kouchuangping granule recurrent aphthae immunoglobulin T lymphocyte subset delayed hypersensitivity anti inflammation and anti exudation

基金项目:江苏省教委自然科学基金!(No .940 63)

作者	单位
过伟峰	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
马骋	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
王永山	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
顾勤	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
汪红	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
王小琴	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
朱翠娣	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
平雷	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
尚文斌	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029
周仲瑛	GUO Weifeng, MA Cheng, WANG Yongshan, et al Nanjing University of TCM, Nanjing (210029

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中文摘要:

目的 :观察清胃泻火养阴法 (口疮平冲剂 )对复发性口疮 (ROU)的临床疗效 ,探讨其作用机理。方法 :对用口疮平冲剂治疗的 148例复发性口疮患者与用雷公藤多甙片治疗的 4 9例患者进行随机对照观察 ,评定其控制溃疡复发、延长发作间歇期、改善局部症状的效果及对体液、细胞免疫功能的影响。通过动物实验 ,观察口疮平冲剂调节免疫功能 ,抗渗出、消炎镇痛等方面的作用。结果 :临床愈显率 6 2 8% ,总有效率 89 9% ,明显优于对照组的 4 0 8%及 75 5% (P <0 0 1,P <0 0 5) ;口疮复发间歇期延长 ,复发时局部症状明显改善 ,与治疗前及对照组比较 ,有显著性差异 (P <0 0 5,P <0 0 1) ;能抑制体液免疫功能 ,增强细胞免疫功能。实验研究表明 ,口疮平能抑制超常的细胞免疫反应 ,防治皮肤粘膜因超敏反应引起的糜烂、破溃 ,抑制毛细血管通透性和白细胞游走 ,减轻 5-羟色胺、组织胺引起的局部肿胀和疼痛。结论 :口疮平冲剂对复发性口疮疗效显著 ,其作用与调节免疫功能 ,消炎消肿、抗渗出有关。

英文摘要:

Objective: To observe the therapeutic effect of Kouchuangping granule (KCP) on recurrent aphthae and explore its mechanism. Methods: One hundred and forty eight patients treated with KCP were observed and compared with 49 patients treated with tripterygii multiglycoside tablet as control in controlling relapse, prolonging intermittent period, improving local symptom and the influence on humoral and cellular immunity. In animal experiment, the effects of KCP on immunologic function, anti exudation, anti inflammation and analgesia were studied. Results: The clinical markedly effective and cure rate of the KCP group was 62.8% and the total effective rate was 89.9%, which were significantly higher than those of the control group (40.8% and 75.5%, P<0 01, P<0 05). In the KCP group, the intermittent period of aphthous ulcer recurrence was prolonged to 6 months and the local symptoms were markedly improved, the differences were significant as compared with those before treatment and those in the control group (P<0 01 or 0.05). The KCP showed effects in suppressing humoral immunity and enhancing cellular immunity. Results of experimental study showed that KCP could inhibit the supernormal reaction of cellular immunity to prevent and treat the hypersentivity caused erosion and ulceration of mucosae, inhibit capillary permeability and WBC migration and abate the 5 hydroxytryptamine (5 HT) and histamine induced local swelling and pain. Conclusion: KCP has a significant effect in treating recurrent aphthae, the mechanism might be related with its effect on immunoregulation, anti inflammation and anti exudation.

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