肝豆汤对肝豆状核变性皮肤成纤维细胞模型铜代谢的影响

作者	单位
汤其强	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
杨任民	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
韩咏竹	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
任明山	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
洪铭范	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
王小平	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
蔡永亮	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
胡纪原	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
李俊	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004
丁莉丽	TANG Qiqiang, YANG Renmin, HAN Yongzhu, et al Department of Neurology, Affiliated Hospital of Bengbu Medical College, Anhui (233004

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中文摘要:

目的 :在细胞水平探讨中药复方肝豆汤治疗肝豆状核变性的机理。方法 :通过建立 2 3例肝豆状核变性皮肤成纤维细胞模型 ,观察加入含肝豆汤兔血清前后细胞内Cu2 + 、Zn2 + 等微量元素含量的变化。结果 :加入含肝豆汤兔血清前与加入 2 4h后相比较 ,细胞内铜含量从 (80 94± 34 76 )ng/mg ,减少到(4 6 90± 2 2 14)ng/mg(P <0 0 1) ,细胞内锌含量从 (140 4 3± 33 81)ng/mg ,增加到 (151 4 3± 37 83)ng/mg(P <0 0 1)。结论 :肝豆汤具有显著的细胞内排铜作用和使细胞内锌含量增加的作用。

英文摘要:

Objective: To explore the cytological mechanism of Gandou Decoction (GDD) in treating hepatolenticular degeneration (HLD). Methods: Twenty three in vitro models of cultured skin fibroblast of HLD were established to observe the intracellular change of microelements (Cu 2+ , Zn 2+ , etc.) content before and after adding rabbit′s serum containing GDD. Results: After being treated with GDD contained serum for 24 hours, the intracellular content of Cu 2+ decreased from (80.94±34.76) ng/mg to (46.90±22.14) ng/mg, P<0 01, while that of Zn 2+ increased from (140.43±33.81) ng/mg to (151.43±37.83) ng/mg, P<0 01. Conclusion: GDD is quite effective in removing the intracellular copper and increasing the intracellular zinc.

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