补肾方药对地塞米松所致实验性骨质疏松大鼠卵巢功能的影响

作者	单位
安胜军	河北医科大学中西医结合基础理论研究室!石家庄050017
李恩	河北医科大学中西医结合基础理论研究室!石家庄050017
赵京山	河北医科大学中西医结合基础理论研究室!石家庄050017

摘要点击次数: 1145

全文下载次数: 1126

中文摘要:

目的 :探讨补肾中药对地塞米松 (DXM )所致实验性骨质疏松 (OP)大鼠卵巢功能的影响。方法 :采用放射免疫分析方法对正常对照组、病理对照组、中药治疗组大鼠生长激素 (GH)、黄体生成素(LH)、卵胞生成素 (FSH)、雌二醇 (E2 )、孕酮 (P)、睾酮 (T)和泌乳素 (PRL)的水平进行比较。并对三组大鼠卵巢、子宫分别称湿重和进行组织形态学观察。结果 :病理对照组与正常对照组大鼠比较GH、LH、FSH、E2和P的水平明显降低 (P <0 0 5) ,子宫和卵巢重量减轻 (P <0 0 5)。中药治疗组与病理对照组相比GH、LH、FSH、E2 和P的水平显著增高 (P <0 0 5) ,子宫和卵巢重量增加 (P <0 0 5)。各组间T和PRL无显著性变化 (P >0 0 5)。组织形态学观察可见补肾中药能明显改善病理状态下大鼠卵巢和子宫的形态结构。结论 :补肾中药能提高大鼠体内GH、LH、FSH、E2 和P的水平 ,使子宫、卵巢重量增加 ,组织形态改善。说明补肾中药对DXM所致实验性骨质疏松大鼠有治疗作用。

英文摘要:

Objective: To investigate the effect of Kidney replenishing herbs (KRH) on ovarian function of experimental rats with dexamethasone induced osteoporosis (OP). Methods: Radioimmunoassay was used to analyse blood level of growth hormone (GH), luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E 2), progesterone (P), testosterone (T) and prolactin (PRL) of animals and data of three groups, the normal control group, the pathologic control group (non treated OP model) and the treated group (model rats treated with KRH) were compared. Weight and histomorphological features of ovary and uterus of the rats were also observed. Results: As compared with the normal control group, levels of GH, LH, FSH, E 2 and P in the pathologic control group were significantly lowered (P<0 05), and the weight of ovary and uterus decreased (P<0 05). In comparison of the treated group and the pathologic group, GH, LH, FSH, E 2 and P levels were significantly higher and weight of ovary and uterus heavier in the treated group (P<0 05). No obvious changes occurred in T and PRL levels. KRH showed markedly improving effect on the ovarian and uterine morphological construction of rats. Conclusions: KRH could elevate the level of GH, LH, FSH, E 2 and P, increase the weight and improve the histomorphologic features of ovary and uterus in OP rats, it demonstrated that KRH has therapeutic effect in treating dexamethasone induced OP rats.

关闭