肾康注射液与苯那普利对肾小球系膜基质作用的对比研究

作者	单位
郭立中	GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029
刘玉宁	GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029
毛炜	GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029
叶传蕙	GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029
顾云	GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029
周姗姗	GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029

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中文摘要:

目的 :探讨肾康注射液与苯那普利对人肾小球系膜细胞外基质 (ECM )不同成分的抑制作用强度。方法 :采用体外培养的人肾小球系膜细胞技术 ,观察具有降逆泄浊、益气活血功效的中药肾康注射液及苯那普利对ECM不同成分的影响。结果 :肾康注射液具有抑制ECM成分中纤维连接蛋白 (FN)、层粘连蛋白 (LN)和Ⅳ型胶原 (ColⅣ )的作用 ,该抑制作用具有一定的量效关系。苯那普利对ECM中FN、ColⅣ也有一定的抑制作用 ,但不及肾康注射液作用明显。结论 :肾康注射液对ECM的抑制作用优于苯那普利。

英文摘要:

Objective: To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM). Methods: Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro. Results: SKI could inhibit the fibronetin, laminin, and type Ⅳ collagen of ECM, and the action was dose dependent. Benazepril could also inhibit the fibronetin and type Ⅳ collagen of ECM but was weaker in intensity. Conclusion: The effect of SKI was superior to Benazepril in inhibiting ECM.

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