中西医结合治疗老年人原发性肾病综合征临床观察

目的:观察中西医结合治疗老年人原发性肾病综合征(INS)的临床疗效。方法:82例老年人INS患者随机分为治疗组和对照组。治疗组(41例)用强的松和环磷酰胺(CTX)并辨证加服中药,对照组(41例)单纯用西药治疗。观察临床缓解率、副反应率、复发率及缓解时间。结果:治疗组完全缓解率(585%)和总缓解率(854%)均显著高于对照组(390%、634%,P<001)。治疗组副反应率(366%)明显低于对照组(805%,P<001)。随访(351±97)个月后,治疗组复发率(83%)与对照组(250%)比较无显著性差异(P>005)。但治疗组平均缓解期为(306±38)个月,较对照组〔(127±37)个月〕显著延长(P<001)。结论:中西医结合治疗老年人原发性肾病综合征优于单纯西医治疗。

英文摘要:

WEI Lianbo, YE Rengao, CHEN Xuhong, et al Nanfang Hospital, The First Military Medical University, Guangzhou (510515) Objective: To observe the clinical effect of integrated traditional Chinese and western medicine (TCM WM) in treating the elderly idiopathic nephrotic syndrome (INS). Methods: Eighty two patients of the elderly INS were randomly divided into the TCM WM group and the control group. Forty one patients of the TCM WM group were treated with prednisone, Cytoxan (CTX) and Chinese medicinal herbs according to Syndrome type, the other 41 patients of the control group were treated with WM alone. Clinical remission rate, adverse reaction, recurrence rate and remission period were observed. Results: The complete remission rate and total remission rate of the TCM WM group were 58.5% and 85.4%, significantly higher than those of the control group (39 0%, 63.4%, P<0 01). The adverse reaction rate of the TCM WM group (36.6%) was significantly lower than that of the control group (80.5%, P<0 01). A follow up of 35.1±9.7 months showed that there was no significant difference in the recurrence rate between two groups (P>0 05), but the average remission period (30.6±3.8 months) of the TCM WM group was significantly longer than that of the control group (12.7±3.7 months, P<0 01). Conclusion: TCM WM treatment is obviously superior to treatment with WM alone in increasing clinical remission rate, relieving adverse reaction rate and extending remission period.

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