乳腺癌患者淋巴细胞功能相关抗原表达水平的临床研究

作者	单位
张瑾	ZHANG Jin, WU Xianzhong, HUANG Jianying, et al The Affiliated Tumor Hospital of Tianjin Medical University, Tianjin (300060
吴咸中	ZHANG Jin, WU Xianzhong, HUANG Jianying, et al The Affiliated Tumor Hospital of Tianjin Medical University, Tianjin (300060
黄建英	ZHANG Jin, WU Xianzhong, HUANG Jianying, et al The Affiliated Tumor Hospital of Tianjin Medical University, Tianjin (300060
于士柱	ZHANG Jin, WU Xianzhong, HUANG Jianying, et al The Affiliated Tumor Hospital of Tianjin Medical University, Tianjin (300060
左联富	ZHANG Jin, WU Xianzhong, HUANG Jianying, et al The Affiliated Tumor Hospital of Tianjin Medical University, Tianjin (300060

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中文摘要:

目的:探讨乳腺癌患者血、癌组织、引流淋巴结中淋巴细胞功能相关抗原CD11a、CD18、CD54蛋白表达水平及化疗和中药益气养血冲剂对其表达水平的影响。方法:免疫组化法和流式细胞术检测乳腺癌患者血、癌组织、引流淋巴结中CD11a、CD18、CD54蛋白表达水平在化疗前、后和化疗加服益气养血冲剂后的改变。结果:乳腺癌患者血中CD54水平与良性对照组比较明显增高,癌组织淋巴细胞CD11a、CD18、CD54水平明显增高,乳腺癌细胞CD54表达阳性率100%,阴性淋巴结CD11a、CD18、CD54表达水平明显高于阳性淋巴结。结论:乳腺癌患者粘附分子水平明显异常,免疫粘附功能障碍,化疗在杀伤癌细胞的同时,对机体免疫功能产生不良影响,益气养血冲剂能够改善化疗后乳腺癌患者淋巴细胞粘附功能等细胞免疫功能。

英文摘要:

To explore the protein expression level of the lymphocyte function related antigen CD11a、CD18、CD54 of breast cancer patients′ blood, cancer tissue and drainage lymph node, and the effect of chemotherapy as well as Yiqi Yangxue Granule on its expression level. Methods: The immnunohistochemical assay and flow cytometry were used to determine the change of the protein expression level of CD11a、CD18、CD54 on the lymphocyte of blood, cancer tissue and lymph node between before and after chemotherapy and chemotherapy plus Yiqi Yangxue Granule in 72 patients suffering from breast cancer. Results: In breast cancer patients, the level of CD54 was increased more obviously than that of control group, the CD11a、CD18、CD54 of lymphocytes in cancer tissue increased remarkably, while the CD54 expression positive rate reached 100%, the expression level of CD11a、CD18、CD54 which increased significantly in negative lymph node obviously higher than that of positive lymph node. Conclusion: The level of adherence cell was markedly abnormal in breast cancer patients, whose immune adherence function disturbed. Although chemotherapy kills the tumor cells, it damages the immune adherence function, Yiqi Yangxue Granule could improve the immune function and enhance the anti cancer effect of patients.

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