胃康复治疗脾虚证胃癌前病变的疗效及其作用机理的研究

Therapeutic Effect or Weikangfu on Gastric Precancerous Disorder with Spleen Deficiency Syndrome and Its Effect of Gastric Mucosal Zinc, Copper, Cyclic Adenosine Monophosphate, Superoxide Dismutase, Lipid Peroxide and 3H-TdR Lymphocyte Conversion

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DOI：

中文关键词: 胃粘膜癌前病变胃康复冲剂环磷酸腺苷超氧化物歧化酶微量元素

英文关键词:gastric mucosa precancerous disorder Weikangfu granule cyclic adenosine monophosphate superoxide dismutase trace element

基金项目:

作者	单位
尹光耀	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041
张武宁	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041
李国成	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041
黄继人	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041
陈一	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041
何雪芬	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041
戴建良	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041
沈小静	YIN Guangyao, ZHANG Wuning, LI Guocheng, et al Wuxi Third People’s Hospital, Jiangsu (214041

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中文摘要:

目的：观察胃康复冲剂治疗胃粘膜肠化生（ＩＭ）和不典型增生（ＡＴＰ）的临床疗效及其作用机理。方法：中西医证病结合，辨证施治，随证加减应用胃康复冲剂作为治疗组（６１例），不予辨证皆用胃苏冲剂作为对照组（５４例），另设健康对照组（１５名）。治疗前后均作胃镜检查，取胃窦部粘膜作病理诊断、组织化学染色进行肠化生分型、胃粘膜Ｚｎ、Ｃｕ、ｃＡＭＰ、ＳＯＤ和血清ＬＰＯ３、3Ｈ－ＴｄＲＬＣＴ检测。结果：（１）治疗组的症状疗效和病理疗效明显优于对照组（Ｐ＜０．０５，Ｐ＜０．０１）。（２）治疗组疗前的胃粘膜Ｚｎ、Ｃｕ、ｃＡＭＰ、ＳＯＤ和３Ｈ－ＴｄＲＬＣＴ均较健康对照组低；治疗后均有提高；血清ＬＰＯ治疗后则随之降低，以上变化均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。结论：胃康复冲剂逆转ＩＭ和ＡＴＰ，是通过改善胃粘膜Ｚｎ、Ｃｕ、ｃＡＭＰ和ＳＯＤ的水平，促进细胞分化，提高细胞免疫功能，降低氧自由基和ＬＰＯ的机制实现的。

英文摘要:

To observe the clinical therapeutic effect of Weikangfu granule (WKF) on intestinal metaplasia (IM), atypical proliferation (ATP) and its therapeutic mechanism. Methods: Sixty-one patients (treated group) were diagnosed by integrated TCM and western medicine (WM), and treated according to Syndrome Differentiation, the amount of WKF was adjusted according to various .Syndromes. The control group consisted of 54 patients, took Weisu granule without considering their Syndromes. Besides, 15 healthy subjects comprised of the control group. Gastroscopy was conducted both before and after the treatment, mucosal sample was taken from antral region of stomach for pathological changes, for IM classification through histochemical staining and for determination of gastric mucosal Zn, Cu, cAMP, SOD, serum LPO and3 H-TdR lymphocyte conversion test (LCT). Results: (1) The symptomatic and pathologic therapeutic effect of the treated group were markedly better than those of the control group (P< 0. 05, P < 0. 01 ). (2)The levels of gastric mucosal Zn, Cu, cAMP, SOD and 3H-TdR LCT of the treated group before treatment were all lower than that of the healthy control group, but they were markedly increased after treatment, while serum LPO, however, increased before treatment, significant difference existed between the above groups (P< 0.05, P< 0.01 ). Conclusion: WKF can reverse IM and ATP of Spleen Deficiency Syndrome through the mechanism of improving the level of gastric mucosal Zn, Cu, cAMP and SOD, promoting cytodifferentiation, improving cytoimmunity, reducing superoxide and LPO.

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