腹腔镜与中药结合治疗卵巢子宫内膜囊肿的临床研究

作者	单位
吴育宁	北京中医医院!北京 100010
华苓	北京中医医院!北京 100010
金延	北京中医医院!北京 100010
张晓辉	北京中医医院!北京 100010
石同淑	北京中医医院!北京 100010
付洁	北京中医医院!北京 100010
滕秀香	北京中医医院!北京 100010

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中文摘要:

目的：探索一种中西医结合治疗卵巢子宫内膜囊肿的新疗法。方法：１５２例卵巢子宫内膜囊肿患者随机采用腹腔镜与中药结合（中西医治疗组）、单纯中药（中药组）、单纯西药（西药组）三种不同方法治疗，观察其疗效及不良反应；并同时检测血清ＣＡ１２５、生殖内分泌激素及血浆前列腺素等。结果：中西医治疗组在囊肿体积缩小率、囊肿消失率、愈显率均优于单纯中药组及西药组（Ｐ＜０．０５，Ｐ＜０．０１）；妊娠率高于西药组（Ｐ＜Ｏ．０５）；无明显不良反应。中西医治疗组疗后血浆前列腺素明显下降（均Ｐ＜０．０１），血清孕酮上升（Ｐ＜０．０５），ＣＡ１２５明显下降（Ｐ＜０．０１）。结论：腹腔镜与中药结合治疗卵巢子宫内膜囊肿是一种疗效较好、不良反应小、最大限度保留生育机能的新方法。

英文摘要:

To investigate a new method of integrated laparoscopy with Chinese herbal medicine (CHM) in treating endometrial ovarian cyst. Methods: One hundred and fifty-two patients with endometrial ovarian cyst were randomly treated with three therapies: Integrated laparoscopy with CHM (combination group), CHM (TCM group) and Danazol (WM group). To compare the clinical efficacy and side-effects of the three groups and to elucidate the therapeutic mechanism by detecting the serum CA125 reproductive endocrine hormone, plasma PGF1a. PGE2 etc. Results: The shrinking rate and disappearance rate of the cysts, and markedly effective rate of combination group were obviously higher than those of TCM group and WM group (P< 0. 05, P< 0.01). The pregnany rate of combination group was also higher than that of WM group (P< 0.5). Few sideeffects were the most prominent advantage for combination group and TCM group. After treatment, the plasma PGF1a. lowered remarkably, serum PO increased and CA125 reduced obviously (P< 0.01, P< 0.05). Conclusion: The integrated laparoscopy and CHM combination therapy is a new method in treating endometrial ovarian cyst with significant efficacy, minimal adverse effect and maximal preservation of reproductive function.

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