豨莶草活性部位抗风湿作用机理研究

作者	单位
钱瑞琴	QIAN Ruiqin, ZHANG Chunying, FU Hongzheng, et al Department of Integrated Traditional Chinese and Western Medicine, Beijing Medical University, Beijing (100O83
张春英	QIAN Ruiqin, ZHANG Chunying, FU Hongzheng, et al Department of Integrated Traditional Chinese and Western Medicine, Beijing Medical University, Beijing (100O83
付宏征	QIAN Ruiqin, ZHANG Chunying, FU Hongzheng, et al Department of Integrated Traditional Chinese and Western Medicine, Beijing Medical University, Beijing (100O83
林文翰	QIAN Ruiqin, ZHANG Chunying, FU Hongzheng, et al Department of Integrated Traditional Chinese and Western Medicine, Beijing Medical University, Beijing (100O83
高子芬	QIAN Ruiqin, ZHANG Chunying, FU Hongzheng, et al Department of Integrated Traditional Chinese and Western Medicine, Beijing Medical University, Beijing (100O83

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中文摘要:

目的：阐明豨莶草抗风湿作用机理。方法：建立佐剂性关节炎（ａｄｊｕｖａｎｔａｒｔｈｒｉｔｉｓ，ＡＡ）大鼠模型。观察豨莶草活性部位对ＡＡ大鼠淋巴细胞增殖反应、白细胞介素一１（ＩＬ－１）、白细胞介素一２（ＩＬ一2）活性的影响，并同时观察ＡＡ大鼠踝关节病理切片，以及豨莶草的镇痛作用。结果：豨莶草可减轻ＡＡ大鼠踝关节炎症等病理反应；有较好的镇痛作用，镇痛率为６５％。豨莶草可增强ＡＡ大鼠Ｔ细胞的增殖功能，促进ＩＬ－２的活性，抑制ＩＬ－１的活性，与对照组比较有显著性差异（Ｐ＜０．０１）。结论：豨荃草可通过调整机体免疫功能，改善局部病理反应而达到抗风湿作用。

英文摘要:

To explore the mechanism of anti-rheumatism action of the active fraction of Herba Siegesbeckiae (AFHS). Methods: Adujvant arthritis model of rat was made to observe the effect of AFHS on lymphocyte proliferation, interleukin-1 (IL-1) and IL-2 activity, pathologic section of ankle joint, and analgesic effect of AFHS in model rat. Results: AFHS could reduce the inflammatory pathologic response of ankle joint, it functions well as analgesics, the analgesic rate being 65%, AFHS could also improve T-lymphocyte proliferation, improve IL-2 activity and inhibit IL-1 activity, as compared with the control group, the difference was significant (P< 0.01 ). Conclusion: Through regulating the immune function of organism, AFHS could improve the local pathologic response so as to antagonise against rheumatism, therefore, it is a good anti-rheumatism herbal medicine.

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