川乌与防己配伍镇痛作用的实验研究

作者	单位
李晓丽	LI Xiaoli, ZHANG Shaohua, QIN Lin, et al Shandong University of TCM, Jinan (250O14
张少华	LI Xiaoli, ZHANG Shaohua, QIN Lin, et al Shandong University of TCM, Jinan (250O14
秦林	LI Xiaoli, ZHANG Shaohua, QIN Lin, et al Shandong University of TCM, Jinan (250O14
宋振华	LI Xiaoli, ZHANG Shaohua, QIN Lin, et al Shandong University of TCM, Jinan (250O14
毛淳	LI Xiaoli, ZHANG Shaohua, QIN Lin, et al Shandong University of TCM, Jinan (250O14
张勤生	LI Xiaoli, ZHANG Shaohua, QIN Lin, et al Shandong University of TCM, Jinan (250O14

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中文摘要:

目的：观察川乌与防己配伍前后镇痛作用的变化。方法：将家兔、小鼠随机分为生理盐水组、消炎痛组、川乌组、防己组、川乌－防己（１：１）配伍组、川乌－防己（１：２）配伍组，利用化学刺激、热刺激、电刺激３种刺激方法，加上扭体实验造成４种实验性疼痛模型，观察川乌、防己配伍前后对家兔、小鼠痛阈的影响。结果：在３ｈ之内各给药组均显示有明显的镇痛作用（Ｐ＜０．０１），其中川乌－防己配伍组和川乌组作用较强；在３ｈ以后，消炎痛组和防己组、川乌组镇痛作用逐渐减弱，至２４ｈ消炎痛组和防己组已无镇痛作用，而川乌－防己配伍组镇痛作用继续增强，并持续较高水平，与消炎痛组和各单味药组比较有显著性差异（Ｐ＜０．０１）。结论：川乌、防己配伍镇痛作用优于单味川芎、防己。

英文摘要:

To explore the changes of analgesic effect of combined Radix Aconiti (RA) and Radix Stephaniae Tetrandrae (RST). Methods: Randomly divide the rabbits and mice into following groups: the blank control group, the positive control group, the RA group, the RST group, the combined RA: RST(1:1) group, the combined RA: RST(1:2) group. Then, using chemical, heat and electrical stimuli, four kinds of pain models were produced, which were to observe the changes of pain threshold of mice before and after using combined RA and RST therapy. Results: Remarkable analgesic effect was obtained in the positive control group and all the groups treated with these two herbs within 3 hours (P< 0.01), and the effect was more obvious in the combined RARST groups and the RA group. The analgesic effect of the positive control group, the RST and the RA group weakened gradually 3 hours later, and at the 24th hour, the effect disappeared in the positive control group and the RST group but it is still remarkable in the combined RA-RST group, which has a significant difference from the positive control group and the groups treated with one single herb (RA or RST). Conclusion: The analgesic effect of the combined RA-RST is superior to the RA and the RST used alone.

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