抗Ⅳ型变态反应中药治疗湿疹的研究

作者	单位
林熙然	LIN Xiran, TU Caixia, YANG Chunmei, et al (Institute of Dermatology, Dalian Medical University, Liaoning (116011
涂彩霞	LIN Xiran, TU Caixia, YANG Chunmei, et al (Institute of Dermatology, Dalian Medical University, Liaoning (116011
杨春梅	LIN Xiran, TU Caixia, YANG Chunmei, et al (Institute of Dermatology, Dalian Medical University, Liaoning (116011
高明阳	LIN Xiran, TU Caixia, YANG Chunmei, et al (Institute of Dermatology, Dalian Medical University, Liaoning (116011
谷玲	LIN Xiran, TU Caixia, YANG Chunmei, et al (Institute of Dermatology, Dalian Medical University, Liaoning (116011

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中文摘要:

在抗Ⅳ型变态反应中药实验研究的基础上，研究治疗湿疹的中药复方。方法：将具有抑制小鼠接触性皮炎作用的中药，按中医治疗湿疹的治则配成不同方剂。研究其对二硝基氟苯诱导小鼠皮炎耳厚度、重量、真皮炎症细胞数和血浆降钙素基因相关肽（ＣＧＲＰ）的影响。以中医治疗湿疹的治则为指导，制成复方茯苓冲剂，用于治疗不包括异位性皮炎的湿疹６３例，与５９例用抗组织胺剂（作用于Ⅰ型变态反应）治疗者比较。结果：实验研究显示中药的４个方剂均有抗Ⅳ型变态反应的作用，其中以凉血清热祛风利湿方作用最强；同时该方还可上调血浆ＣＧＲＰ浓度。口服复方茯苓冲剂的治疗组临床治愈率４７．６％，对照组临床治愈率２２．０％，两组比较，有显著性差异（ｕ＝２．９５５５，Ｐ＜０．０１）。结论：中药有抗Ⅳ型变态反应的作用，复方茯苓冲剂治疗湿疹有较好的疗效。

英文摘要:

To study Chinese herbal prescription for treatment of eczema based on the suppressive effect Chinese herbal medicine on type Ⅳ allergic reaction. Methods: Various formulae composed of Chinese herbal medicines possessing suppressive effect on allergic contact dermatitis were formed based on the therapeutic principles of traditional Chinese medicine in treating eczema, and their effect on murine ear swelling, ear flake weight, dermal inflammatory infiltration cell count and plasma level of calcitonin gene related peptide (CGRP) were examined in mice with dinitrofluorobenzene induced dermatitis. A prescription, Composite Poria Decoction was formulated and made into granule form, which was used to treat 63 cases of eczema (atopic dermatitis was excluded), and compared with 59 cases treated with antihistamine that was aimed at the type I allergic reaction. Results: Experimental study showed that all the 4 Chinese prescriptions had the effect of anti-type Ⅳ allergic reaction, among them, the formula for cooling blood, remove Heat, Wind and Dampness evil possessed the most potent effect in suppressing murine dermatitis, and it was also able to up-regulate the plasma CGRP concentration. The clinical cure rate of Composite Poria Granule treatment was 47.6%, and that of control was 22.0%, the difference was significant between the two groups (u=2. 9555, P<0.01). Conclusions: Chinese herbal medicine has effect of anti-type Ⅳ allergic reaction. Composite Poria Granule has good effect in treating eczema.

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