利心丸治疗充血性心力衰竭的临床研究

目的：观察利心丸对充血性心力衰竭的治疗效果。方法：将90例心功能Ⅲ～Ⅳ级的充血性心力衰竭患者随机分为A、B、C3组，分别用利心丸、利心丸加小剂量地高辛及常规剂量地高辛治疗，疗程均为1个月；全部患者均常规服用利尿剂、硝酸酯类及血管紧张素转换酶抑制剂作为基础治疗。结果：A、B、C3组患者心功能总有效率分别为83．3％、93．3％和90．0％，B组与A、C组比较均有显著性差异（P＜0．05）。3组患者左室射血分数均显著提高，以B组为优（P＜0．05）；舒张晚期／舒张早期最大血流速度（A／E）比值A、B组均显著改善（P＜0．05，P＜0．01）。A、B两组患者并发的室上性早搏及室性早搏总数均较治疗前显著减少（P＜0．01，P＜0．05）。结论：利心丸与小剂量地高辛合用治疗充血性心力衰竭可明显提高疗效。

英文摘要:

To observe the clinical therapeutic effect of Lixin Pill (LXP) in treating patients with congestive heart failure (CHF). Methods: Ninety CHF patients with heart function of Ⅲ-Ⅳ grade were randomly divided into 3 groups. Group A was treated with LXP, Group B with LXP plus small dosage of digoxin and Group C with ordinary dosage of digoxin. The therapeutic course for all the three groups was 1 month. Meanwhile, all patients were given ordinary dosage of diuretics, nitrates and angiotensin- converting enzyme inhibitors (ACEI)as basic therapy. Results: The total effective rate in improving heart function in Group A, B and C was 83. 3 %,93. 3 % and 90. 0% respectively. In respect of improving myocardial contraction and dilation, the left ventricular ejection fraction (LVEF) was improved in all the three groups but was more superior in Group B (P <0.05);the ratio of maximum blood flow between the advanced and the early diastolic stage (A/E) was improved, and the complicated supraventricular and ventricular premature contraction in Group A and B were reduced markedly after treatment (P<0. 01 or P < 0.05), and the effect in Group B was superior to that in Group A. Conclusion: Using LXP combined with small dosage of digoxin could improve the therapeutic effect in treating patients suffering from congestive heart failure.

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