电针缓解吗啡戒断大鼠的心动过速

目的：建立吗啡戒断大鼠心动过速模型，观察不同频率电针对其心率的影响。方法：给大鼠连续注射递增量吗啡8天，造成其对吗啡依赖。停药后18～24h给于强度为1mA，频率为2Hz、15Hz、100Hz的电针刺激，记录清醒状态下吗啡戒断大鼠的心率和血压。结果：与正常大鼠比较吗啡戒断大鼠心率显著增快（P＜0．01），但平均动脉压无显著性差异。15Hz和100Hz电针对吗啡戒断大鼠的心动过速均有显著抑制作用（使心率降低分别为13．1％、13．4％，P＜0．01），而2Hz无抑制作用。结论：临床使用经皮电刺激降低阿片依赖患者心动过速的治疗作用可以在大鼠模型中得到重复。

英文摘要:

To establish morphine withdrawal tachycardia model of rat and to observe the effect of elec-troacupuncture (EA) with different frequency on its heart rate. Methods: Morphine dependence was induced inWistar rats by injection of morPhine for 8 days successively, and EA 1 rnA in strength was given after withdraw-alof morphine with different frequencies of 2 Hz, 15Hz and 100Hz, the heart rate and blood pressure wererecorded in the awaked rats. Result8: Morphine abstinent rats showed a 24% increase of heart rate as comparedwith that of the normal control group, but no significant change was observed in blood pressure. The lOOHz and15Hz EA produced a 13. 4% and 13. 1 % decrease of heart rate respectively, whereas 2Hz EA produced insignifi-cant change. Conclusion: The reducing effect of percutaneous electric stimulation on tachycardia in heroin ad-dicts revealed clinically can be replicated in the rat model.

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