银杏叶提取物对反复脑缺血再灌注损伤的保护作用

作者	单位
周兰兰	ZHOU Lan-lafy MING Liang, J1ANG Qin, et al Ddertment 0f Pharmacol0gy, Anhui Medical University, Hoti(230032
明亮	ZHOU Lan-lafy MING Liang, J1ANG Qin, et al Ddertment 0f Pharmacol0gy, Anhui Medical University, Hoti(230032
江勤	ZHOU Lan-lafy MING Liang, J1ANG Qin, et al Ddertment 0f Pharmacol0gy, Anhui Medical University, Hoti(230032
马传庚	ZHOU Lan-lafy MING Liang, J1ANG Qin, et al Ddertment 0f Pharmacol0gy, Anhui Medical University, Hoti(230032

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中文摘要:

目的：研究银杏叶提取物（FGE）对反复脑缺血再灌注损伤的保护作用。方法：采用清醒小鼠造成反复脑缺血再灌注模型，应用避暗法、跳台法、比色法观察了FGE对小鼠行为、氧自由基代谢及前列腺素E2（PGE2）含量的影响。结果：FGE可以明显改善反复脑缺血再灌注小鼠的学习、记忆功能，同时可不同程度地抑制其脑组织中异常升高的丙二醛、一氧化氮和PGE2含量，并可明显增强脑组织中降低的超氧化物歧化酶和过氧化氨酶活性。结论：FGE对反复脑缺血再灌注损伤有显著的保护作用，其机制可能与抗脂质过氧化、增强抗氧化酶活性及抑制PGE2生成有关。

英文摘要:

To study the protective effect of extract of Folium Ginkgo (FGE) 0n repeated cerebral ischemia-reperfusi0n injury. Methods: The model in waking mice induced by repeated cerebral ischemia-reperfusion wereused in the experiment to observe the effect of FGE on behavior, oxygen free radical metabolism andprostaglandin E2 (PGE2 ) content by step-through experiment, diving stand and colorimetric method. ResultsFGE could obviously improve the learning ability and memory of model animals, and could lower obviously thecontent of malonyldialdehyde, nitric 0xide and PGE2, restore the lowered activity of superoxide dismutase andcatalase in cerebral tissue. C0nclusi0n: FGE has highly protective effect against repeated ischemia-reperfusioninjury, the mechanism might be related with its action on anti-lipid oxidatin, improve the activity of antioxidaseand inhibit the producing of PGE2.

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