银杏内酯类合成物F抗血小板激活因子和组织胺的实验研究

目的：研究银杏内酯类合成物F（简称药物F）同时拮抗组织胺（HA）和血小板激活因子（PAF）的作用。方法：测定离休豚鼠肺组织的收缩率以及用药物F后的致敏豚鼠肺功能的变化。结果：（1）加入药物F后离体豚鼠的气管条和肺条对HA的收缩率分别由（50．97±16．00）％和（54．2±12．17）％降至（21．69±3．85）％和（22．97±17．78）％（P＜0．05）;（2）药物F保护后，离体豚鼠肺条对PAF的相对收缩率由（89．49±16．00）％降至（46．21±14．23）％（P＜0．05）；（3）药物F保护的豚鼠致敏后，其肺功能较对照组有改善趋势。结论：药物F能同时拮抗离体豚鼠肺组织对HA和PAF的收缩反应，并有改善致敏豚鼠肺功能的趋势，可望用于支气管哮喘的治疗。

英文摘要:

To investigate the antagonizing effect of synthetic Ginkgolide F (SGF) on platelet-activating factor (PAF) and histamine (HA) in guinea-pigs. Methods: The contraction rate of isolated lung tissue of guinea-pig and the change of pulmonary function of sensitized guinea-pig after SGF treatment were examined.Results: (1) The contraction rate of guinea-pigs’ isolated trachea and lung strip induced by HA reduced from (50. 97 ± 16.00) % and (54.24 ± 12. 17) % to (21. 69 ± 3. 85) % and (22. 97 ± 17. 78) % after SGF treatment (P <0.05). (2) PAF induced relative contraction of isolated guinea-pig lung strip was reduced from (89. 49± 16. 00) % to (46 .21 ± 14. 23) % in presence of SGF (P < 0.05). (3) The pulmonary function of sensitized animal had a tendency of being improved by SGF. Conclusion: SGF can antagonize the contraction of isolated lung tissue induced by HA or PAF in vitro, and has a tendency to improve the pulmonary function of sensitized guinea-pig, therefore, it may be a promising drug in treatment of bronchial asthma.

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