| 黄兆胜,王宗伟,刘明平,荣向路,吴庆光,黎俏梅.虎金丸对肝纤维化大鼠血清Ⅲ型前胶原、透明质酸及层粘蛋白作用的动态观察[J].中国中西医结合杂志,2000,(6):447-449 |
| 虎金丸对肝纤维化大鼠血清Ⅲ型前胶原、透明质酸及层粘蛋白作用的动态观察 |
| Observation on Dynamic Changes of Serum Procollagen Ⅲ, Hyaluronic Acid and Laminin in Rats with Hepatic Fibrosis Treated with Hujin Pill |
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| DOI： |
| 中文关键词: 虎金丸 肝纤维化 Ⅲ型前胶原 透明质酸 层粘蛋白 |
| 英文关键词:Hujin pill liver fibrosis procollagen Ⅲ hyaluronic acid laminin |
| 基金项目:国家中医药管理局重点资助!97A06 |
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| 中文摘要: |
| 目的：观察虎金丸对肝纤维化大鼠血清Ⅲ型前胶原（procollagenⅢ，PCⅢ）、透明质酸（hyaluronicacid，HA）及层粘蛋白（laminin，LN）的动态影响。方法：采用CCl4所致肝纤维化动物模型，用放免法检测血清PCⅢ、HA、LN。结果：虎金丸能显著降低各期模型大鼠血清中HA、LN的含量，与对照组比较有显著性差异（P＜0．05，P＜0．01）。长期疗效优于秋水仙碱组。能维持血清中PCⅢ的血清含量在肝纤维化期（9、12周）基本正常，与正常对照组比较无显著性差异（P＞0．05）。结论：虎金丸能延缓肝纤维化的形成，有较好的预防和治疗效果。 |
| 英文摘要: |
| Objective: To study the dynamic changes of serum procollagen Ⅲ (PC Ⅲ ), hyaluronic acid (HA) and laminin (LN) in rats with hepatic fibrosis treated with Hujin pill (HJP). Methods: The classic model of hepatic fibrosis induced by CCl4 were used in the observation. The serum PCⅢ, HA and LN were determined by ra dioimmunoassay (RIA). Results: WP could reduce the serum HA, LN content significantly, as compared with the control group, the difference was significant (P<0. 05, P<0. 01). Its long-term therapeutic effect was better than that df colchicine. It could maintain the serum PCⅢ stable in hepato-fibrotic stage (9 ~ 12 weeks), as compared with the normal control group, the difference was insignificant (P > 0.05). Conclusion: HJP could retard the liver fibrosis, and has good preventive and therapeutic effect on liver fibrosis in rats. |
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