针刺对肥胖大鼠下丘脑外侧区单胺类递质和ATP酶活性的影响

作者	单位
刘志诚	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)
孙凤岷	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)
韩燕	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)
朱苗花	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)
王沂争	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)
魏群利	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)
苏静	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)
王耿	LIU Zhicheng, SUN Fengmin, HAN Yan, et al (Nanjing University of Traditional Chinese Medicine, Nanjing (210029)

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中文摘要:

目的：了解针刺对单纯性肥胖病的作用机制。方法：采用中枢神经核团推挽灌流和生化技术，观察针刺对单纯性肥胖病胃肠实热型大鼠的肥胖指标以及下丘脑外侧区（ＬＨＡ）单胺类神经递质含量和ＡＴＰ酶活性的变化。结果：肥胖组ＬＨＡ去甲肾上腺素（ＮＡ）含量高于正常组（Ｐ＜０．０５），而５－羟色胺（５－ＨＴ）含量及ＡＴＰ酶活性低于正常组，（Ｐ＜０．０５，Ｐ＜０．０１）。针刺使肥胖大鼠减肥同时，使ＬＨＡ中ＮＡ含量回降，５－ＨＴ含量、Ｍｇ~２－ＡＴＰ酶及Ｃａ~２－ＡＴＰ酶活性回升（Ｐ＜０．０５，Ｐ＜０．０１）。结论：针刺对肥胖大鼠ＬＨＡ的调整作用可能是针刺减肥的关键因素之一。

英文摘要:

To study the mechanism of acupuncture in treating simple obesity. Methods: Central nerve push-pull perfusion and biochemical technique were used to observe the effect of acupuncture on obese rats, and the obese parameters and the change of monoamine transmitters and activity of ATPase in the lateral hypothalamic area (LHA) of the obese rats were investigated. Results: The levels of noradrenaline (NA) in LHA of obese rats were higher than those in the normal group, but the level of serotonin (5-HT) and the activity of ATPase in LHA of obese rats were lower than those of the normal rats. After acupuncture treatment, the weight of the obese rats reduced, while the level of NA in LHA reduced and the 5-HT and activity of ATPase increased (P< 0. 05, P < 0. 01 ). Conclusion: The effective regulation on LHA of obese rats is possibly one of the key factors in the anti-obesity of acupuncture.

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