平喘口服液治疗支气管哮喘的临床和实验研究

作者	单位
王志英	WANG Zhiying, ZHOU Zhongying, JIN Miaowen, et al. Nanjing University of TCM, Nanjing (210029
周仲瑛	WANG Zhiying, ZHOU Zhongying, JIN Miaowen, et al. Nanjing University of TCM, Nanjing (210029
金妙文	WANG Zhiying, ZHOU Zhongying, JIN Miaowen, et al. Nanjing University of TCM, Nanjing (210029
许惠琴	WANG Zhiying, ZHOU Zhongying, JIN Miaowen, et al. Nanjing University of TCM, Nanjing (210029
束建清	WANG Zhiying, ZHOU Zhongying, JIN Miaowen, et al. Nanjing University of TCM, Nanjing (210029
奚肇庆	WANG Zhiying, ZHOU Zhongying, JIN Miaowen, et al. Nanjing University of TCM, Nanjing (210029
汪红	WANG Zhiying, ZHOU Zhongying, JIN Miaowen, et al. Nanjing University of TCM, Nanjing (210029

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中文摘要:

目的 :观察平喘口服液对支气管哮喘的临床疗效 ,并探讨其作用机理。方法 :以化痰祛瘀 ,降气平喘为基本治疗大法 ,研制了寒喘平口服液 (简称寒喘平组 )和热喘平口服液 (简称热喘平组 ) ,分别治疗哮喘发作期患者 50例和 55例 ,以桂龙咳喘宁胶囊为对照 (对照组 52例 ) ,并进行了动物实验研究。结果 :临床总有效率寒喘平组为 88 0 % ,热喘平组为 90 9% ,均明显优于对照组 ( 73 1% ,P <0 0 5)。在改善临床症状和体征 ,降低外周血嗜酸性粒细胞、免疫球蛋白 (IgE) ,改善肺功能等指标方面 ,两平喘药组与对照组比较差异有显著性 (P <0 0 5或P <0 0 1)。实验研究结果表明 :平喘口服液能降低血浆血栓素B2 、内皮素含量 ,升高血清一氧化氮、血浆 6 酮前列腺素F1α含量。结论 :平喘口服液对支气管哮喘疗效显著 ,其作用与调节免疫功能、抗过敏、拮抗炎性介质有关

英文摘要:

Objective: To observe the clinical effect of Pingchuan oral liquid, including Hanchuan oral liquid (HCOL) and Rechuan oral liquid (RCOL), and to explore its mechanism. Methods: HCOL and RCOL were prepared based on the therapeutic principles of eliminate phlegm, remove blood stasis, lower reversed Qi flow and relieve asthma. HCOL was used to treat 50 patients of bronchial asthma in Group A and RCOL for 55 patients in Group B, and they were compared with 52 patients treated with Guilong Kechuanning capsule in the control group. The relevant animal experiment was also conducted. Results: The total effective rate of HCOL was 88.0%, that of RCOL was 90.9%, they were significantly higher than that of the control (73.1%, P<0 05). Moreover, the two new preparations showed the effects in easing main symptoms and signs of asthma, decreasing peripheral eosinophilic granulocyte count and immunoglobulin level, and improving pulmonary function superior to those of Guilong Kechuanning capsule (P<0 05, P<0 01). Experimental study showed that they could lower blood thromboxane B 2 and endothelin, raise blood nitric oxide and 6 keto prostaglandin F 1α . Conclusion: Pingchuan oral liquid is obviously effective in treating bronchial asthma, the mechanism possibly lays on adjusting immune function, anti allergy and antagonizing inflammatory media.

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